Assessing the Effects of Increased Mitochondrial Function and Chronic Aerobic or Resistance Exercise Training on Skeletal Muscle Performance in Older Men; a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Change in mitochondrial function
研究概览
简要总结
As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability of muscle to perform physical activity. There is some evidence that supplements may improve how the mitochondria work, and investigators want to explore this idea in more detail. This is possible by measuring how the muscles work and respond to exercise before and after taking the supplement alongside an aerobic (i.e. cycling) and resistance (i.e. weight lifting) exercise programme. This will give us the basic information investigators would need to see if this is a useful idea.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 75 Years（Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age between 65-75 years
- •Body mass index between 19-29
- •No active cardiovascular or metabolic disease
- •No active respiratory disease
- •No current musculoskeletal injuries
- •A sedentary lifestyle (i.e. does not engage in strenuous, planned physical activity)
- •The ability to give informed consent
排除标准
- •Currently taking a statin drug or NSAIDs
- •Have a current peptic ulcer
- •Have any renal impairment
- •Have a known hypersensitivity to Acipimox
- •Suffer from vertigo
研究组 & 干预措施
Placebo plus exercise training
The placebo supplement will contain only cellulose microcrystalline. This is an inert substance widely used in many pill and tablet formulations. It is an insoluble fibre and is not absorbed into the blood stream therefore is unlikely to cause toxicity when taken orally.
干预措施: Placebo (Dietary Supplement)
Acipimox plus exercise training
The active supplement will contain the prescription drug Acipimox (250 mgs) , a nicotinic acid precursor traditionally used to lower blood lipid levels. The supplement will be administered 3 times per day, for 6 weeks.
干预措施: Acipimox (Dietary Supplement)
结局指标
主要结局
Change in mitochondrial function
时间窗: Baseline, 3 weeks, 6 weeks
Mitochondria will be extracted from muscle samples immediately post-biopsy (biopsies taken baseline, week 3 and week 6) and analysed for content and subsequently for oxidative respiratory function using the Oroboros technique, and maximal rates of Adenosine Triphosphate (ATP) production.
次要结局
- Chronic changes in habitual muscle protein synthetic rates(Baseline, 3 weeks and 6 weeks)