comparing efficacy of preoperative magnesium sulphate nebulization with ketamine nebulization in reducing incidence of severity of post operative sore throat in patient undergoing surgery under general anesthesia.,

Phase 2

Not yet recruiting

• Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical,

• Registration Number: CTRI/2024/04/065794
• Lead Sponsor: dr vaishnav

Brief Summary

We will be nebulizing patients with magnesium sulfate 250mg and ketamine 50mg over 15 minutes and then follow up patients for developing pharnygolaryngeal complications.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-04-15
• Study Start: 2024-04-26

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1.Males and females between the age group 18-60 years.
• ASA class I-II.
• Body mass index(BMI) 18.5-29.9. 4.
• Undergoing surgeries requiring general anaesthesia with cuffed ETT of duration 60-120 minutes.

Exclusion Criteria

• Patient’s refusal participation in study.
• Haemodynamically unstable patients.
• History of hypertension, asthma, chronic obstructive pulmonary disease(COPD), cardiovascular disease, renal disease, diabetes mellitus, cerebrovascular disease.
• Patients having known hypersensitivity to drugs under consideration.
• Patient with three or more attempts at laryngoscopy or bougie for intubation.
• Patients who sustained trauma while intubation or nasogastric tube insertion as evidenced by blood on cuff after extubation or blood stained secretions while suctioning before extubation.
• Patient suffering from active or recent (past 6 weeks) upper airway tract infection (preoperative sore throat, cough) and edema/inflammation noticed during laryngoscopy.
• Surgery requiring placement of nasogastric tube intraopeartively.
• Patients already on analgesics or steroids (systemic or inhaled).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PRIMARY OBJECTIVES	2,4,6,12,24,48 hours
1. To Evaluate & compare the effectiveness of nebulised Magnesium sulfate & ketamine in:	2,4,6,12,24,48 hours
2. To access the airway dynamics during surgery & extubation.	2,4,6,12,24,48 hours
a. Extubation Quality using 5 point extubation quality score.	2,4,6,12,24,48 hours
b. Post extubation airway related adverse effects like cough (POC), sore throat (POST) & hoarseness (POH).	2,4,6,12,24,48 hours
3. To study side effect of study drugs if any.	2,4,6,12,24,48 hours
4. Patient satisfaction score.	2,4,6,12,24,48 hours
SECONDARY OBJECTIVES	2,4,6,12,24,48 hours
1. To access the haemodynamic parameter during surgery & extubation.	2,4,6,12,24,48 hours

Secondary Outcome Measures

Name	Time	Method
SECONDARY OBJECTIVES	1.To access the haemodynamic parameter during surgery and extubation.

Trial Locations

Locations (1)

Dr Rajendra Prasad Governent Medical College Tanda,Kangra.; 🇮🇳 Kangra, HIMACHAL PRADESH, India

Dr Rajendra Prasad Governent Medical College Tanda,Kangra.

🇮🇳Kangra, HIMACHAL PRADESH, India

Dr Vaishnav

Principal investigator

7411276092

vaishnavrgpmc@gmail.com