ISRCTN18430630
已完成
未知
Deep brain stimulation for severe obsessive compulsive disorder: efficacy and mechanisms of ventral striatum and subthalamic nucleus targets
niversity College London0 个研究点目标入组 6 人2015年4月22日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- 未指定
- 发起方
- niversity College London
- 入组人数
- 6
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
2019 results in https://www.ncbi.nlm.nih.gov/pubmed/30853111 (added 31/03/2020)
研究者
入排标准
入选标准
- •The inclusion criteria have been designed to be consistent with previous OCD DBS studies and to ensure that patients have not responded in a useful and sustained manner to either modifications of medication or any form of CBT
- •1\. Patients must have undergone intensive treatment and have demonstrable treatment resistance as defined by:
- •1\.1\. At least two SRIs for a minimum of 12 weeks at optimal British National Formulary (BNF) doses
- •1\.2\.Augmentation of SRI treatment with antipsychotic drugs administered at maximally tolerated doses or by extending the SSRI dose beyond BNF limits
- •1\.3\. Two trials of CBT of at least 10 hours
- •1\.4\. Failed inpatient treatment
- •2\. Patients must also satisfy the following criteria:
- •2\.1\. Age \> 20 years
- •2\.2\. Confirmation of a primary diagnosis of obsessive compulsive disorder (ICD10 F42\.0—F42\.9\)
- •2\.3\. Duration of illness of at least 10 years
排除标准
- •1\. Current diagnoses of substance misuse (ICD10 F10—F19\), organic brain syndrome (ICD10 F00—F09\), adult personality disorder (ICD10 F60—F69\), pervasive developmental disorder (ICD10 F84\); schizophrenia (ICD10 F20\-F29\) and bipolar disorder (ICD 10 F30\-31\)
- •2\. Contraindications to neurosurgery
- •3\. Pregnancy
结局指标
主要结局
未指定
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