Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection

Phase 2

Completed

Interventions: Dietary Supplement: Oral calcium plus vitamin D
Dietary Supplement: Oral calcium alone

Brief Summary: the increased risk of hypocalcemia following total thyroidectomy plus central neck dissection can be minimized by routine administration of oral calcium and vitamin D supplements during the early postoperative period.

Detailed Description: Of patients with differentiated papillary thyroid carcinoma, group D underwent total thyroidectomy alone and groups A-C underwent total thyroidectomy plus CND. The latter were randomized to oral calcium (3 g/day) plus vitamin D (1 mcg/day) (group A, n = 49), calcium alone (group B, n = 49), or no supplements (group C, n = 50). Hypocalcemic symptoms, serum calcium, and parathyroid hormone (PTH) levels were compared among the groups.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Previous thyroid or neck surgery
Patients with parathyroid diseases
Other thyroid malignancies
Early loss of follow-up without proper evaluation of postoperative serum calcium levels and symptoms

Arm && Interventions

Group	Intervention	Description
A	Oral calcium plus vitamin D	Oral calcium plus vitamin D supplements after total thyroidectomy and central neck dissection
B	Oral calcium alone	Oral calcium alone supplement after total thyroidectomy and central neck dissection

Primary Outcome Measures

Name	Time	Method
The clinical utility of calcium and vitamin D supplements for prevention of hypocalcemia following total thyroidectomy plus central neck dissection	To postoperative 12 months

Secondary Outcome Measures

Name	Time	Method

Locations (1): Chungnam National University Hospital
🇰🇷
Daejeon, Korea, Republic of

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