The Effectiveness of High-flow Nasal Cannula After Extubation in Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- ROX index
研究概览
简要总结
Observe the current status of prolonged mechanical ventilation (PMV) patients using high-flow nasal cannula oxygen therapy (experimental group) or traditional oxygen therapy (control group) after extubation, and compare the differences in ventilator weaning rates between the two groups.
Record the ROX index (SpO2/FiO2/RR) at 2, 6, 12, and 24 hours after extubation in PMV patients and explore whether statistical methods can predict the weaning outcome within seven days.
Use statistical methods to analyze whether comorbidities in the PMV population affect ventilator weaning rates.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 20 years old and expected to undergo extubation.
排除标准
- •Patients with tracheostomy who will use non-invasive or invasive ventilators immediately after extubation.
结局指标
主要结局
ROX index
时间窗: From enrollment to preliminary data compilation, lasting a total of 4 months.
The oxygen concentration used before and after oxygen therapy adjustment is recorded as percent, accompanied by clinical and physiological parameter the patient's oxygen saturation (SpO₂) and respiratory rate (breaths per minute). Additionally, multiple measurements of the ROX index are performed, combining saturation (SpO₂), FiO₂, and respiratory rate to calculate and report the ROX index (SpO₂ / FiO₂ / RR).
P/F ratio
时间窗: From enrollment to preliminary data compilation, lasting a total of 4 months.
Collect the arterial oxygen partial pressure (PaO₂, mmHg) from each patient's clinical arterial blood dialysis, and compare it with the oxygen concentration (%) being used at the time. The two values are then combined to calculate the P/F ratio (PaO₂, mmHg / FiO₂, decimal).
次要结局
未报告次要终点
研究者
Lo Tzu Han
Principal Investigator
Chang Gung Memorial Hospital