Arginine supplementation in severe sepsis: effects on metabolism and microcirculation.

Completed

• Conditions: Severe sepsis or septic shock ICU patients.

• Registration Number: NL-OMON21371
• Lead Sponsor: ovartis Consumer Health - R&D Nutrition.

Brief Summary

1. Luiking, Y. C., Poeze, M., Dejong, C. H., Ramsay, G. & Deutz, N. E. (2004) Sepsis: an arginine deficiency state? Crit Care Med 32: 2135-2145.<br> 2. Bruins, M. J., Soeters, P. B., Lamers, W. H. & Deutz, N. E. (2002) L-arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. Am J Clin Nutr 75: 1031-1044.<br> 3. Bruins, M. J., Luiking, Y. C., Soeters, P. B., Lamers, W. H., Akkermans, L. M. & Deutz, N. E. (2004) Effects of long-term intravenous and intragastric L-arginine intervention on jejunal motility and visceral nitric oxide production in the hyperdynamic compensated endotoxaemic pig. Neurogastroenterol Motil 16: 819-828.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

1. Written informed consent from close relative;

2. Age > 18 years;

Exclusion Criteria

1. Shock due to any cause other than sepsis (e.g. drug reaction or drug overdose, pulmonary embolus, burn injury, severe blood loss etc.);

2. Prolonged or high dose corticosteroid use;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microcirculation.

Secondary Outcome Measures

Name	Time	Method
1. Arginine metabolism;<br /><br>2. Hemodynamics;<br /><br>3. Vascular permeability;<br /><br>4. Organ functions;<br /><br>5. Disease severity scores.