eural Correlates of Apathy In Mild Cognitive Impairment (MCI)

Completed

• Conditions: apathy; dementia; 10057167; 10012272

• Registration Number: NL-OMON41265
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

All subjects:
- Age from 60yrs to 80yrs
- Willingness to cooperate and sign written informed consent;Normal Healthy Controls:
- MMSE scores between 28 and 30;aMCI with apathy
-Diagnosis of aMCI as assessed by clinician and neuropsychologist, according to Petersen 1999.
-Apathy diagnosed by apathy criteria (Robert 2009), assessed by clinician and neuropsychologist ;aMCI without apathy
-Diagnosis of aMCI as assessed by clinician and neuropsychologist, according to Petersen 1999
-Apathy excluded according to apathy criteria (Robert 2009), assessed by clinician and neuropsychologist

Exclusion Criteria

All subjects:
-Medications which may affect the experimental outcomes
-Existence of psychiatric conditions with exception of depression or neurological conditions or problems with eyesight
-MR incompatible implants in the body (such as ear prosthesis, pacemakers, implanted heart valves etc). All subjects have to fill out a detailed questionnaire covering safety aspects of the research in relation to the 3 Tesla magnetic field and the MRI environment.
-Any risk of having metal particles in the eyes due to manual work without proper eye protections
-Tattoos containing red pigments that form a safety risk
-Claustrophobia
-The refusal to be informed of structural brain abnormalities that could be detected during the experiment ;Normal Heathy Controls:
-Abnormal result on any neuropsychological test
-Diagnosis of AD by NINCDS/ADRDA criteria (McKhann 1984) and DSM-IV criteria, assessed by clinician and neuropsychologist

aMCI with apathy, aMCI without apathy
-Diagnosis of AD by NINCDS/ADRDA criteria (McKhann 1984) and DSM-IV criteria, assessed by clinician and neuropsychologist

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Functional MRI data will be analysed for areas of activation and functional<br /><br>connectivity between these areas while Diffusion Weighted Imaging will be used<br /><br>to study the structure of tracts. Metabolite abnormalities will be assessed<br /><br>using a Magnetic Resonance Spectroscopy scan. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>