eural Correlates of Apathy In Mild Cognitive Impairment (MCI) - Apathy and Memory

niversitair Medisch Centrum Groningen0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•All subjects:
•- Age from 60yrs to 80yrs
•- Willingness to cooperate and sign written informed consent;Normal Healthy Controls:
•- MMSE scores between 28 and 30;aMCI with apathy
•-Diagnosis of aMCI as assessed by clinician and neuropsychologist, according to Petersen 1999.
•-Apathy diagnosed by apathy criteria (Robert 2009), assessed by clinician and neuropsychologist ;aMCI without apathy
•-Diagnosis of aMCI as assessed by clinician and neuropsychologist, according to Petersen 1999
•-Apathy excluded according to apathy criteria (Robert 2009), assessed by clinician and neuropsychologist

•All subjects:
•-Medications which may affect the experimental outcomes
•-Existence of psychiatric conditions with exception of depression or neurological conditions or problems with eyesight
•-MR incompatible implants in the body (such as ear prosthesis, pacemakers, implanted heart valves etc). All subjects have to fill out a detailed questionnaire covering safety aspects of the research in relation to the 3 Tesla magnetic field and the MRI environment.
•-Any risk of having metal particles in the eyes due to manual work without proper eye protections
•-Tattoos containing red pigments that form a safety risk
•-Claustrophobia
•-The refusal to be informed of structural brain abnormalities that could be detected during the experiment ;Normal Heathy Controls:
•-Abnormal result on any neuropsychological test
•-Diagnosis of AD by NINCDS/ADRDA criteria (McKhann 1984) and DSM-IV criteria, assessed by clinician and neuropsychologist
•aMCI with apathy, aMCI without apathy
•-Diagnosis of AD by NINCDS/ADRDA criteria (McKhann 1984) and DSM-IV criteria, assessed by clinician and neuropsychologist

发起方