Low Grade Inflammation in Childhood Obesity : an Independent Risk Factor for Endothelial Dysfunction
- Conditions
- InflammationObesity, ChildhoodObesityEndothelial DysfunctionCardiovascular Risk Factor
- Interventions
- Diagnostic Test: AnthropometryDiagnostic Test: Blood pressureDiagnostic Test: Peripheral arterial tonometryOther: QuestionnaireDiagnostic Test: Blood sample
- Registration Number
- NCT04181398
- Lead Sponsor
- Universitair Ziekenhuis Brussel
- Brief Summary
Eligible candidates will be recruited within the children with overweight and obesity having a metabolic risk evaluation before treatment in the period 2006 and 2010 at the pediatric clinic of the UZ Brussel In total 60 participants will be investigated. Firstly, 30 participating patients with initially elevated hsCRP will be selected at random ( following the date of their initial investigation) and afterwards matched for age, BMI z-score, and blood pressure with the same number of patients without initially elevated hCRP values
Data will be collected as follows:
* questionnaires
* clinical examination/ anthropometry
* blood sample (hsCRP)
* peripheral arterial tonometry (endoPAT)
- Detailed Description
Obesity and overweight have become an important health burden in children and adolescents, with 19% of all children between 5 and 18 years being either obese or overweight in Belgium. Obesity and especially visceral adiposity early in life may contribute to the development of cardiovascular disease at older age, as it shows tracking into adulthood and is be associated with cardiovascular risk factors such as dyslipidemia, insulin resistance, arterial hypertension and low grade inflammation, in a variable percentage.
Low grade inflammation, as assessed by hSCRP, was found to be present in 20.6 % and 19.8 % of overweight children and adolescents. In adults, hSCRP levels between 1 and 3 mg/L and above 3 mg/L are considered coronary disease risk factors.
Endothelial dysfunction, know to precede the formation of atherosclerotic plaque, can be assessed in a non-invasive manner in children by peripheral artery tonometry. Only few studies have been performed in obese children with this bed-side technique, showing either normal of a disturbed function, reflected by a lower reactive hyperemia index. The association with low grade inflammation however was assessed in only one study. The investigators hypothesize that in adolescents and young adults with a history of childhood obesity a more disturbed endothelial function will be present in those with and /or current elevated hSCRP value.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Age 12-21 years at the moment of evaluation
- BMI > 1.3 Standard Deviation Score at the initial evaluation
- Hs-CRP available at initial evaluation
- Acute of chronic Infection at the time of the study visit
- Be or have been a smoker of tabacco
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Baseline high hs-CRP Blood pressure Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline high hs-CRP Blood sample Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline low hs-CRP Blood sample Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline high hs-CRP Anthropometry Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline high hs-CRP Questionnaire Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline high hs-CRP Peripheral arterial tonometry Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline low hs-CRP Anthropometry Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline low hs-CRP Blood pressure Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline low hs-CRP Questionnaire Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP) Baseline low hs-CRP Peripheral arterial tonometry Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP)
- Primary Outcome Measures
Name Time Method Endothelial cell function through study completion, an average of 1 year (measured once) Reactive hyperemia index (RHI) measured by the EndoPAT device.
- Secondary Outcome Measures
Name Time Method hs CRP level through study completion, an average of 1 year (measured once) The investigators also hypothesized that low grade inflammation, and thus a rise in hs-CRP, will be persistent overtime.
BMI z-score through study completion, an average of 1 year (measured once) The researchers want to investigate the evolution of the level of the obesity of the participants over time
Fat percentage by skin fold measurements through study completion, an average of 1 year (measured once) The researchers want to investigate the evolution of the level of the obesity of the participants over time
Trial Locations
- Locations (1)
University Hospital of Brussels
🇧🇪Brussels, Belgium