NCT01178463UnknownNot Applicable
Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia
Hillel Yaffe Medical Center1 site in 1 country25 target enrollmentStarted: January 2010Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Hillel Yaffe Medical Center
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- SSCs were identified in both obstructive and nonobstructive azoospermia patients.
Study Overview
Brief Summary
The researchers hypothesized that nonobstructive azoospermia might be associated with a reduction OF SSCs in seminiferous tubules as compared with obstructive azoospermia. Testicular sperm specimens that had been previously extracted from azoospermic patients will be paraffin embedded and stained with anti GPR-125. After antigen retrieval, the sections will be incubated with rabbit anti GPR125 followed by Cy3-conjugated anti rabbit secondary antibodies. Those found to be SSCs will be counted using light microscopy, and compared between patients with obstructive (n=11) and non-obstructive azoospermia (n=9).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Azoospermic patients
Exclusion Criteria
- •Patients with sperm cells
Outcomes
Primary Outcomes
SSCs were identified in both obstructive and nonobstructive azoospermia patients.
Time Frame: One year
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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