Multidisciplinary Team IntervenTion in CArdio-ONcology (TITAN Study)
- Conditions
- Breast Cancer
- Interventions
- Behavioral: Multidisciplinary team intervention
- Registration Number
- NCT01621659
- Lead Sponsor
- University of Alberta
- Brief Summary
People with breast cancer often experience many short and long-term side effects as a result of both the cancer and the necessary treatments.
Receiving extra assessments and care from teams of multiple health professionals has been shown to be helpful for people with other health problems, such as heart disease. These 'multidisciplinary' teams may include nurses, doctors, pharmacists, dietitians, exercise therapists, counselors, and other specialists. Currently, the investigators do not know if receiving extra assessments from a multidisciplinary team is helpful for people receiving cancer treatment.
In this study, the investigators hope to learn the effect of extra assessments and early interventions from teams of health care professionals in people diagnosed with cancer, during and after the treatment period.
After initial assessments, participants will be randomized to multidisciplinary team intervention or usual care.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 80
- histologically confirmed malignancy (breast or lymphoma);
- scheduled to receive anthracycline and/or trastuzumab-based chemotherapy;
- age ≥ 18 years;
- willing to attend follow-up visits.
- physical disability preventing exercise testing or DEXA scan;
- psychiatric disease or disorder precluding informed consent;
- participation in other cardiotoxicity or exercise intervention study;
- contraindication to anti-cancer therapy, including known heart failure, cardiomyopathy, or baseline LVEF < 50%;
- previous anthracycline or trastuzumab-based therapy;
- previous radiotherapy to thorax.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description multidisciplinary team intervention Multidisciplinary team intervention Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist
- Primary Outcome Measures
Name Time Method cardiac MRI change from baseline to 12 months left ventricular ejection fraction (LVEF)
- Secondary Outcome Measures
Name Time Method serum biomarkers change from baseline to 12 months percent change in established biomarkers (troponin, BNP)
Trial Locations
- Locations (1)
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada