Role of ultrasound derived kidney index and urine and serum biomarkers in determining the type of kidney injury in patients with liver disease
- Conditions
- Other and unspecified cirrhosis ofliver, (2) ICD-10 Condition: N179||Acute kidney failure, unspecified,
- Registration Number
- CTRI/2020/09/027816
- Lead Sponsor
- Dr Ajay Kumar
- Brief Summary
This study is a prospective observational single centre study comparing the diagnostic accuracy of renal resistive index, urine NGAL and serum IL-6 for differentiating the type of acute kidney injury in patients of cirrhosis with acute kidney injury, in 70 patients over 12 months. The primary outcome measure will be differentiating ATN vs Non-ATN AKI on day 3. The secondary outcome measure will be differentiating Pre Renal AKI, HRS-AKI, ATN-AKI on day 3.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 70
Diagnosed cases of cirrhosis with AKI (≥ Stage IB, Serum creatinine ≥ 1.5mg/dL).
Hypertension Diabetes Mellitus Renovascular disease CKD Prior Kidney or Liver Tramsplant Acute or Chronic Renal Replacement Therapy at the time of enrolment Other causes of renal insufficiency like intrinsic causes of AKI other than ATN (like glomerulonephritis) or urinary Obstruction Confirmed pregnancy UTI.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differentiating between ATN(Acute Tubular Necrosis) and Non-ATN AKI(Acute Kidney Injury) 3 Days
- Secondary Outcome Measures
Name Time Method Differentiating between Pre-renal AKI, HRS(Hepatorenal Syndrome)-AKI, ATN-AKI 3 Days
Trial Locations
- Locations (1)
G.B. Pant Institute of Postgraduate Medical Education and Research(GIPMER)
🇮🇳Central, DELHI, India
G.B. Pant Institute of Postgraduate Medical Education and Research(GIPMER)🇮🇳Central, DELHI, IndiaDr Ajay KumarPrincipal investigator9718599226ajaykumar.aiims@gmail.com