NL-OMON26885尚未招募不适用
Randomized controlled trial to assess the effect of vitamin D plus K supplementation on the rate of elastin degradation in COPD
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- one
- 入组人数
- 40
研究概览
简要总结
/A
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Diagnosed with COPD based on post-bronchodilator FEV1/FVC <0.70 according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.
- •Serum 25(OH)D<50 nmol/L
- •Age =40 and =75 years at screening visit
排除标准
- •Subjects using vitamin K as supplements <3 months prior to the screening visit
- •Use of vitamin K antagonists (i.e acenocoumarol, fenprocoumon) in 12 months prior to the screening visit
- •Exacerbation <6 weeks prior to the screening visit
- •Use of digoxin and/or thiazide diuretics
- •Hypercalcemia (i.e. corrected calcium for albumin >2.8 mmol/L)
- •Kidney stones in medical history
- •Severe renal failure (i.e. eGFR < 30 ml/min/1.73 m2)
- •Hyperparathyroidism
研究者
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