EVALUATION OF YOGAVAHITVA OF MADHU WITH SPECIAL REFERENCE TO SAMYOGA ON ANTI- HYPERGLYCAEMIC ACTIVITY OF TRIPHALA IN PRE-DIABETES – A RANDOMIZED OPEN LABELLED CONTROLLED CLINICAL STUDY

Diabetes Mellitus is one of the largest global public health concerns, imposing a heavy global burden on public health as well as Socio-economic development. Diabetes Atlas 2021 reports that 10.5% of the adult population ranging from 20-29 years have Diabetes. By 2045, IDF projections show that 1 in 8 adults, will be living with Diabetes, an increase of 45%. In India, there are estimated 77 million people above the age of 18 years and nearly 25 million are prediabetics with more than 50% of people are unaware of their diabetic status. Hyperglycaemia-induced oxidative stress is central to the development of diabetes. Studies have shown that polyphenols could reduce and reverse oxidative stress associated hyperglycemia. Phenolics due to their poor bioavailability often fail in getting absorbed properly from gut and hence need bio-availability enhancers, which could bring enhanced effects. Honey has lower glycemic index and decreases the fasting blood glucose. Honey protects against metabolic syndrome by exerting antidiabetic activity. It keeps the gut healthy as it increases the bioavailability of Phenolics which are digested by the Gut microbe. The active principles of Triphala are predominantly hydrolysable tannins. Their antioxidant activity of Triphala correlates with their Antidiabetic property. Adults treated with Intensive Lifestyle Treatment have chances of achieving remission of diabetes.