A prospective randomised study to compare intravenous paracetamol as preemptive vs preventive analgesic on postoperative pain in open elective below umbilical surgeries under general anaesthesia in paediatric patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Time to first rescue paracetamol after extubation
研究概览
简要总结
Background:
Managing postoperative pain in children is challenging due to their limited ability to express pain and the risks of traditional analgesics like opioids and NSAIDs. Intravenous paracetamol is a safer alternative with proven efficacy. Pre-emptive analgesia (administering analgesics before surgical trauma) may reduce pain and analgesic needs compared to preventive analgesia (after surgery).
Purpose:
The trial compares the effectiveness of intravenous paracetamol given pre-emptively versus preventively on postoperative pain in pediatric patients undergoing elective open below-umbilical surgeries under general anesthesia.
Objectives:
• Primary: Time to first rescue paracetamol dose.
• Secondary: Total analgesic consumption, pain scores, side effects, and parental satisfaction within 24 hours post-surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 4.00 Year(s) 至 14.00 Year(s)（—）
- 性别
- All
入选标准
- •weight more than 10kgs open abdominal surgeries operation time less than 120 minutes ASA 1 and ASA2.
排除标准
- •Refusal of patients attendant/guardian 2) psychiatric illness.
- •H/O allergy /hypersensitivity to paracetamol, NSAIDS 4) Haemodynamically unstable patients.
- •Hepatic and renal dysfunctions 6) Use of anticoagulants.
结局指标
主要结局
Time to first rescue paracetamol after extubation
时间窗: 1 hr, 24 hr
次要结局
- 1. Total paracetamol consumption in 24hours post surgery(mg)(2. Total number of patients requiring rescue paracetamol)
研究者
Mushahid Raza Khan
Jawaharlal nehru Medical College,Aliagrh Muslim University