EXplaining PLasticity after stroke

Completed

Conditions: Cerebrovasculair Accident CVA
Stroke
10007963

Registration Number: NL-OMON39598

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

regarding the primary objective: 1) an upper limb deficit, i.e. a NIHSS score of 1-4 in the second week post stroke; 2) a first-ever ischemic lesion in the territory of the MCA, verified by CT and/or MRI scan; 3) age between 40 and 75 years; 3) written or oral informed consent; 4) be able to sit for 30 seconds without support. Regarding the secondary objective: patients > 1 year post stroke with a motor deficit of the upper extremity NHSS *1; healthy volunteers within expected age range of stroke survivors, i.e. 40-75 years.

Exclusion Criteria

1) a pacemaker or other metallic implants; 2) upper extremity orthopaedic limitations; 3) not being able to communicate i.e. < 4 points on the
Utrecht Communication Observation; 4) a Mini Mental State Examination, MMSE score of 22 points or less and 5) successful recombinant tissue plasminogen activator (rTPA, or alteplase) treatment.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>primary: cortico- muscular coherence, i.e. the concordance between brain and<br /><br>muscle activity at different brain areas, expressed as a fraction</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary: clinical outcome as measured by the Action Research Arm Test (ARAT),<br /><br>Motricity Index (MI) of arm and leg, Fugl-Meyer for the arm (FM-arm), Erasmus<br /><br>modification of the Nottingham Sensory Assessment (EmNSA), Letter Cancellation<br /><br>Task (LCT), Nine Hole Peg test (NHPT), a structured participant interview of<br /><br>real arm use using the Motor Activity Log (MAL), Stroke Impact Scale (SIS<br /><br>version 3.0) and Nottingham Extended ADL (NEADL).</p><br>