Pediatric Radio Frequency Coils Generic

Active, not recruiting

• Conditions: Duchenne Muscular Dystrophy; Musculoskeletal Abnormalities

• Registration Number: NCT01633866
• Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Brief Summary

The purpose of this study is to evaluate and optimize advances in radio frequency (RF) coil magnetic resonance imaging (MRI) technology at Cincinnati Children's Hospital Medical Center (CCHMC).

Detailed Description

Pediatric Magnetic resonance (MR) imaging techniques have been limited by the unavailability of specialized radio-frequency (RF) coils for pediatric imaging. Typically, MR coils are designed for general purpose adult imaging and lack the mechanical design, flexibility and high channel count needed for pediatric imaging. Furthermore, pediatric patients are often positioned decubitus or prone rather than supine. This makes coil positioning even more challenging and often results in images with low SNR and poor image quality. Many coils used in clinical practice have fixed dimensions that do not fit within the realm of "one-size fits all," especially for the huge variation found in the pediatric patient population.

MRI coil development and optimization is performed by MR manufacturers and in research laboratories across the world including the Imaging Research Center (IRC) of Cincinnati Children's Hospital and Medical Center (CCHMC). Coil development and refinement involves evaluating the new coils on inert phantoms and then imaging examinations performed on healthy participants and patients. The focus of this study protocol is to evaluate the design and performance of investigational coils on patients and healthy participants.

Study Timeline

• Study First Submitted: 2012-06-21
• Study Start: 2012-07
• Study First Submitted QC: 2012-07-02
• Study First Posted: 2012-07-04
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-11
• Last Update Posted: 2024-12-16
• Primary Completion: 2025-06
• Study Completion: 2025-06

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Healthy participants:

• Male or Female
• Thermally stable
• Any age

Clinical patients:

• Male or Female
• Thermally stable
• any age

Exclusion Criteria

Healthy participants & Clinical patients

• Female participants who are pregnant or lactating
• Subjects iwth standard contraindications to MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of participants with adverse events as measured by heating and comfort participant response	Day 1

Secondary Outcome Measures

Name	Time	Method
MRI Image Quality	2 Weeks Post MRI Scan

Trial Locations

Locations (1)

Cincinnati Children's; 🇺🇸 Cincinnati, Ohio, United States