Mucosal Innate Immune Activation in Chronic Intestinal Disorders
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- The number of specimens showing elevated levels of mucosal innate immune activation
研究概览
简要总结
Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome (IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or constipation, and blood in the stool. It is not known what causes diseases such as IBD and IBS. This study will look at the events in the gut that leads to leaky gut and inflammation in patients with IBD and IBS. The study will also see if medications such as rifaximin and mesalamine may reduce the amount of leaky gut.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women, 18-years old and older
- •Presenting at the University of Arkansas for Medical Sciences (UAMS) Endoscopy center to undergo endoscopy with biopsy for surveillance, screening or diagnosis.
排除标准
- •Subjects classified in an anesthesia risk group , American Society of Anesthesiologists Class (ASA) ≥ 4,
- •history of bleeding diathesis or coagulopathy
- •stroke or transient neurological attack within the last 6 months
- •pregnancy
- •currently on blood thinners (excepting aspirin)
- •subject is unable to consent themselves
结局指标
主要结局
The number of specimens showing elevated levels of mucosal innate immune activation
时间窗: Up to 2 years
Determining the level of mucosal innate immune activation by staining, organoid culture, Western blot analysis, and cytokine expression on biopsy samples in IBD and IBS patient samples.
次要结局
未报告次要终点