NCT00516776CompletedNot Applicable
The Innate Immune System and Inflammatory Bowel Disease
Norwegian University of Science and Technology1 site in 1 country400 target enrollmentStarted: June 2007Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- gene expression patterns in mucosal biopsies
Study Overview
Brief Summary
The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands relevant for stimulation of the IIS and study the immune response. Colonic mucosal samples are examined to find gene expression patterns which may distinguish the two forms of disease from each other and from healthy controls.
The hypothesis is that the innate immune system has responses unique for the disease states, and that the diseases may be differentiated by examination of gene expression patterns in mucosal biopsies.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Presence of ulcerative colitis
- •Presence of Crohn's disease
- •Healthy (no sign of inflammatory bowel disease)
Exclusion Criteria
- •Anticoagulation
- •Cardiac valvular disease
- •Intravascular prosthesis
- •Coagulation disorders
- •Gastrointestinal malignancy
Outcomes
Primary Outcomes
gene expression patterns in mucosal biopsies
Time Frame: 2 years
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
Loading locations...
Similar Trials
Recruiting
Not Applicable
Immune Regulation in Ulcerative Colitis or Crohn s DiseaseChrohn's DiseaseUlcerative ColitisInflammatory Bowel DiseaseNCT00001184National Institute of Allergy and Infectious Diseases (NIAID)1,000
Withdrawn
Not Applicable
Mucosal Innate Immune Activation in Chronic Intestinal DisordersInflammatory Bowel DiseasesIrritable Bowel SyndromeNCT03529318University of Arkansas
Completed
Not Applicable
A Study on Administration Choices of Vedolizumab and Outcomes for Adults With Inflammatory Bowel Disease (IBD) (VARIETY - CROATIA AND SLOVENIA)Inflammatory Bowel DiseasesCrohns DiseaseColitis, UlcerativeNCT04885920Takeda120
Unknown
Not Applicable
Development of a Questionnaire Based on Patients' Messages on an Internet Forum for Flare Detection in IBDInflammatory Bowel DiseasesNCT04180345Central Hospital, Nancy, France260
Completed
Not Applicable
Clinical Observational Study: IBD Patients With Restless-legs-syndrome and Iron Deficiency SyndromeInflammatory Bowel DiseasesRestless Legs SyndromeIron-deficiencyNCT03457571Charite University, Berlin, Germany353