Efficacy of 0.1% chlorine dioxide mouthwash in reducing oral malodour

Not Applicable

Completed

• Conditions: Oral malodour/halitosis; Oral Health; Halitosis

• Registration Number: ISRCTN75902618
• Lead Sponsor: niversity of Medicine and Pharmacy, Ho Chi Minh City

Brief Summary

2018 results in https://pubmed.ncbi.nlm.nih.gov/30386642/ (added 27/07/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-04-30
• Study Start: 2018-03-15
• Last Update Posted: 10 August 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

1. First- to third-year students at the University of Medicine and Pharmacy, Ho Chi Minh City who had halitosis as a chief complaint
2. An organoleptic score = 2 based on the Rosenberg scale (Rosenberg & McCulloch, 1992)
3. A level of H2S > 1.5 ng/10 mL or CH3SH > 0.5 ng/10 mL (1) determined by OralChromaTM

Exclusion Criteria

1. Gastrointestinal diseases or respiratory diseases
2. Habit of smoking
3. Wearing dentures or orthodontic appliances
4. Undergoing any antibiotic treatment 1 month before and during the study course

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
VSC concentration measured with hydrogen sulphide (H2S) and methyl mercaptan (CH3SH) gas analysis machine at baseline, 12 hours and 2 weeks

Secondary Outcome Measures

Name	Time	Method
<br> 1. Organoleptic score measured directly by an examiner using 0-5 scale at baseline, 12 hours and 2 weeks<br> 2. Plaque index (PI) and gingival index (GI) assessed using the method of Loe and Silness (Loe, 1967), and bleeding on probing (BOP) evaluated at four sites (distal, buccal, mesial and lingual) on all teeth except for third molars at baseline, 12 hours and 2 weeks<br> 3. Evaluation of tongue coating based on the criteria of Winkel et al. (2003) at baseline, 12 hours and 2 weeks<br> The pH of resting saliva determined by a pH paper test (Saliva-Check Buffer Kit, GC, Japan) at baseline, 12 hours and 2 weeks<br> 4. Detection and determination of bacterial species A. actinomycetemcomitans, F. nucleatum, P. gingivalis, S. moorei, S. salivarius, T. denticola and T. forsythia in resting saliva using a multiplex real-time polymerase chain reaction (PCR) assay at baseline and after 2 weeks<br>