Comparing the pain relief effect of two types of pain killers in patients of hernia surgery

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2016/08/007217
• Lead Sponsor: Government Medical College and Hospital

Brief Summary

Pain after surgery is inevitable and if not adequately controlledcan adversely affect both physical and physiological functions. Inadequaterelief of postoperative pain can prolong recovery, increase the duration ofstay in the hospital and increase health care costs.Unrelievedacute pain is often associated with sleeplessness, anxiety, fear, ordemoralization and may lead to the development of chronic pain syndromes. Effective pain managementis an important component of post-surgical care.  The latest innovation in this class of compounds with the novelmechanism of action is tapentadol. Tapentadol shares the same dual-actionmechanism as tramadol, but is devoid of the the disadvantages of tramadolmentioned. Thus, it represents a theoretical and practical advancement inpain management.To the best of our knowledge, so far there areno studies comparing the analgesic efficacy and tolerability of oraltapentadol-paracetamol combination vs. oral tramadol-paracetamol combinationfor postoperative pain relief in patients undergoing hernia surgery

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03-06
• Last Update Posted: 2018-12-14

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 120

Inclusion Criteria

Under going inguinal hernia surgery ASA status I and II.

Exclusion Criteria

• 1.ASA status > III 2.Major co-existing medical illness (especially severe asthma/COPD, epilepsy, uncontrolled hypertension or diabetes, liver or renal disease) 3.Patients with paralytic ileus 4.Patients on tricyclic antidepressants, anticonvulsants, Mono amino oxidase inhibitors, antipsychotics or serotonin-norepinephrine reuptake inhibitors (i.e. within 30 days) 5.
• Known hypersensitivity to any of the study medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain at rest and on movement measured by visual analog scale (VAS)	During the postoperative period at intervals of 0 hour (when the first dose of the combination is administered, i.e., when the block level recedes to T10), 2, 4, 8, 12, and 24 h

Secondary Outcome Measures

Name	Time	Method
Haemodynamics,Patient Satisfaction Scale , rescue analgesics, adverse effects	During the postoperative period at intervals of 0 hour (when the first dose of the combination is administered, i.e., when the block level recedes to T10), 2, 4, 8, 12, and 24 h

Trial Locations

Locations (1)

Department of Anaesthesia and Intensive Care; 🇮🇳 Chandigarh, CHANDIGARH, India

Department of Anaesthesia and Intensive Care

🇮🇳Chandigarh, CHANDIGARH, India

Sukanya Mitra

Principal investigator

09646121521

drsmitra12@yahoo.com