Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI)

Phase 3

Completed

Conditions: Coronary Artery Disease
Angina Pectoris

Interventions: Drug: Placebo
Drug: Ranolazine

Registration Number: NCT01442038

Lead Sponsor: Gilead Sciences

Brief Summary: This study will evaluate the efficacy of ranolazine as compared with placebo when used as part of standard medical therapy in chronic angina subjects with incomplete revascularization post-percutaneous coronary intervention (PCI; formerly known as angioplasty with stent) on the composite of ischemia-driven revascularization or ischemia-driven hospitalization without revascularization.

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 2651

Inclusion Criteria

Written informed consent
Males and females aged 18 years and older
History of chronic angina defined as at least 2 episodes of anginal pain or discomfort in the chest, jaw, shoulder, back, neck, or arm that is precipitated by exertion or emotional stress, and relieved by rest or sublingual nitroglycerin, which occurred on at least 2 separate days and at least 14 days prior to PCI (in the case of staged PCI procedures, at least 14 days prior to the first PCI in the series). Participants may or may not have additional angina episodes within the 14 days prior to their first PCI in the series, as well as any time prior to Randomization.
PCI for any indication (ACS or non-ACS). For the purposes of stratification at randomization, ACS will be defined as hospitalization for anginal pain or discomfort within the previous 24 hours to their hospitalization with any one (or more) of the following criteria:

i. Elevated troponin or creatinine kinase-MB (CK-MB) consistent with myocardial infarction (MI), as reported by local laboratory and measured prior to index PCI ii. Electrocardiographic changes (including transient changes) comprising new or presumably new ST segment depression ≥ 0.1 mV (≥ 1 mm), or ST segment elevation ≥ 0.1 mV (≥ 1 mm) in at least 2 contiguous leads, or new or presumably new Left Bundle Branch Block
Randomization within 14 days post-PCI. In the case of staged PCI procedures, randomization has to occur within 14 days of the last PCI in the series. Participants may be randomized starting on the day of PCI and anytime during the following 14 days. PCI is defined as an attempt to cross the lesion with a wire with the intention of performing revascularization.
Post-PCI (post the last PCI for staged procedures) evidence of incomplete revascularization defined as the presence of one or more visually estimated ≥ 50% stenoses in one or more coronary arteries with reference vessel diameter of at least 2.0 mm, whether in the target vessel or in a non-target vessel regardless of the presence or absence of coronary collaterals. In the case of a participant post-coronary artery bypass grafting (CABG), incomplete revascularization is defined as the presence of one or more visually estimated ≥ 50% stenoses in an unbypassed epicardial vessel with a reference diameter of ≥ 2.0 mm, or one or more visually estimated ≥ 50% stenoses in a bypass graft supplying an otherwise unrevascularized myocardial territory.
Clinically stable post-PCI. Participants randomized in-hospital on day of planned discharge or in clinic are considered stable. Participants randomized in-hospital prior to day of planned discharge must meet all of the following criteria:

i. CK-MB < 3 times the upper limit of normal (ULN) at least 3 hours post-PCI, or if ≥ 3 times the ULN with evidence of decreasing CK-MB (decreased by at least 20% from the prior measurement) as reported by local laboratory. If CK-MB is not available, a participant must have evidence of normal or decreasing troponin levels (by at least 20% from the prior measurement) at least 3 hours post-PCI, as reported by local laboratory.

ii. Systolic blood pressure ≥ 90 mm Hg and not receiving pressors or inotropes iii. No current requirement for an intra-aortic balloon pump (IABP) or any left ventricular assist device iv. No current requirement for intravenous (IV) nitroglycerin
Ability and willingness to comply with all study procedures during the course of the study
Females of childbearing potential must have a negative pregnancy test at Screening (unless surgically sterile or post-menopausal) and must agree to use highly effective contraception methods from Screening throughout the duration of study treatment and for 14 days following the last dose of study drug.

Exclusion Criteria

Any future planned revascularization (including staged procedures) or possible planned revascularization (ie, planned stress test to assess the imminent need for additional revascularization). Future planned stress tests for purposes of monitoring are permitted but strongly discouraged. Participants may be enrolled after the last PCI in the staged series or once a decision is made not to perform a follow up PCI, as long as Randomization occurs within 14 days from the last PCI. If a participant has had a stress test post-PCI and prior to Randomization and no further intervention is planned, the participant may be enrolled within 14 days from the last PCI.
Unrevascularized left main coronary artery stenosis ≥ 50%. Participants with a history of CABG to the left coronary system will be considered to have a revascularized left main if at least one graft is patent.
Major complication during or after the index PCI (in the case of staged PCI, the last in the series) including:

i. Major bleeding (TIMI Bleeding classification or any bleeding requiring blood transfusion of ≥ 2 units of red blood cells) ii. Coronary perforation requiring treatment iii. Procedural complication requiring surgery (including CABG or peripheral vascular surgery)
Stroke within 90 days prior to Randomization, or any history of stroke with permanent major neurologic disability (eg, aphasia or significant motor dysfunction)
Cardiogenic shock within 90 days prior to Randomization (transient decreases in blood pressure without clinical sequelae are not considered to be cardiogenic shock)
New York Heart Association (NYHA) Class III or IV heart failure
Severe renal insufficiency as assessed by an estimated glomerular filtration rate < 30 mL/min/1.73m2 using the 4 variable modification of diet in renal disease (MDRD) equation per local laboratory (based on the last available measurement prior to Randomization, collected within 1 month prior to the index PCI [in the case of staged PCI, the last in the series])
Liver cirrhosis
Use of Class Ia, Ic, or Class III antiarrhythmics, except for amiodarone
Current treatment with strong inhibitors of CYP3A
Current treatment with CYP3A4 inducers or P-gp inducers
Participants taking > 20 mg simvastatin daily or > 40 mg lovastatin daily who cannot reduce the dose to 20 mg once daily for simvastatin or 40 mg once daily for lovastatin, or who cannot switch to another statin
Participants taking greater than a total of 1000 mg daily of metformin who cannot reduce the dose to a maximum total of 1000 mg daily (additional anti-diabetic medications may be added as clinically indicated to allow participants to decrease their metformin dose and maintain glycemic control)
Previous treatment with ranolazine for > 7 consecutive days within 30 days prior to Randomization, or known hypersensitivity or intolerance to ranolazine or to any of the excipients
Participation in another investigational drug or investigational device study within 30 days prior to Randomization (participation in registries is allowed)
Women who are pregnant or breast feeding
Non-coronary artery disease comorbid conditions (eg, advanced malignancy, severe aortic stenosis) which are likely to result in death within 2 years of Randomization
Any condition that in the opinion of the investigator would preclude compliance with the study protocol

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	-
Ranolazine	Ranolazine	-

Primary Outcome Measures

Name	Time	Method
Kaplan-Meier Estimates for Time From Randomization to First Occurrence of Ischemia-driven Revascularization or Ischemia-driven Hospitalization Without Revascularization	Baseline through end of study (average 90 weeks)	Time to event distributions were estimated by the Kaplan-Meier (KM) method. 1 month = 28 days; 1 calendar year = 365 days.

Secondary Outcome Measures

Name	Time	Method
Kaplan-Meier Estimates for Time From Randomization to Sudden Cardiac Death	Baseline through end of study (average 90 weeks)	Time to event distributions were estimated by the Kaplan-Meier method. 1 month = 28 days; 1 calendar year = 365 days.
Kaplan-Meier Estimates for Time From Randomization to Cardiovascular Death	Baseline through end of study (average 90 weeks)	Time to event distributions were estimated by the Kaplan-Meier method. 1 month = 28 days; 1 calendar year = 365 days.
Kaplan-Meier Estimates for Time From Randomization to Myocardial Infarction	Baseline through end of study (average 90 weeks)	Time to event distributions were estimated by the Kaplan-Meier method. 1 month = 28 days; 1 calendar year = 365 days.

Trial Locations

Locations (208): Tallahassee Research Institute
🇺🇸
Tallahassee, Florida, United States
Union Memorial Hospital
🇺🇸
Baltimore, Maryland, United States
Veterans Administration Medical Center
🇺🇸
Pittsburgh, Pennsylvania, United States
Broward General Medical Center
🇺🇸
Fort Lauderdale, Florida, United States
Cardiology Associates of Fairfield County, PC
🇺🇸
Stamford, Connecticut, United States
Holy Name Medical Center
🇺🇸
Teaneck, New Jersey, United States
New York Methodist Hospital
🇺🇸
Brooklyn, New York, United States
Central New York Cardiology
🇺🇸
Utica, New York, United States
Stony Brook University Medical Center
🇺🇸
Stony Brook, New York, United States
Asheville Cardiology Associates
🇺🇸
Asheville, North Carolina, United States
Imelda Ziekenhuis
🇧🇪
Bonheiden, Antwerpen, Belgium
Algemeen Ziekenhuis Sint-Jan
🇧🇪
Brugge, West-Vlaanderen, Belgium
Hospital Universitario La Paz
🇪🇸
Madrid, Spain
Utah Cardiology, PC
🇺🇸
Layton, Utah, United States
Innsbruck Universitaetsklinik
🇦🇹
Innsbruck, Tyrol, Austria
Hôpital Bichat-Claude Bernard
🇫🇷
Paris, Ile-de-France, France
University of Tennessee
🇺🇸
Knoxville, Tennessee, United States
University Health Network
🇨🇦
Toronto, Ontario, Canada
Fakultní nemocnice Královské Vinohrady
🇨🇿
Praha, Czech Republic
Centre Hospitalier d'Arras
🇫🇷
Arras, Nord Pas-De-Calais, France
ZOL Genk, Campus Saint Jan
🇧🇪
Genk, Limburg, Belgium
Royal Alexandra Hospital
🇨🇦
Edmonton, Alberta, Canada
University of Alberta Hospital
🇨🇦
Edmonton, Alberta, Canada
Fakultní nemocnice Brno
🇨🇿
Brno, Czech Republic
Hamilton Health Sciences, General Site
🇨🇦
Hamilton, Ontario, Canada
University of Vermont Medical Center, Fletcher Allen Health Care
🇺🇸
Burlington, Vermont, United States
Humble Cardiology Associates
🇺🇸
Humble, Texas, United States
Karlovarská krajská nemocnice a.s.
🇨🇿
Karlovy Vary, Karlovarský kraj, Czech Republic
Fakultní nemocnice Olomouc
🇨🇿
Olomoucký kraj, Czech Republic
Krajská nemocnice Liberec a.s.
🇨🇿
Liberec, Liberecký kraj, Czech Republic
Fondazione Centro S. Raffaele del Monte Tabor, Ospedale San Raffaele
🇮🇹
Milano, Italy
Kaplan Medical Center
🇮🇱
Rehovot, Reheoboth, Israel
Kerckhoff-Klinik GmbH
🇩🇪
Bad Nauheim, Hessen, Germany
Edith Wolfson Medical Center
🇮🇱
Holon, Israel
American Heart of Poland S.A.
🇵🇱
Ustron, Slaskie, Poland
SPZOZ, Samodzielny Publiczny Centralny Szpital Kliniczny w Warszawie
🇵🇱
Warszawa, Poland
Azienda Ospedaliera "Maggiore della Carita" di Novara
🇮🇹
Novara, Italy
Republic Clinical Hospital № 2
🇷🇺
Kazan, Russian Federation
City Clinical Hospital n.a. S.P.Botkin
🇷🇺
Moscow, Russian Federation
Centre Hospitalier d'Annecy
🇫🇷
Pringy, Rhone-Alpes, France
Instytut Kardiologii
🇵🇱
Warszawa, Mazowieckie, Poland
Wojewódzki Szpital Zespolony im. Ludwika Rydygiera w Toruniu
🇵🇱
Torun, Poland
Ospedali Riuniti di Bergamo
🇮🇹
Bergamo, Italy
Medical Center "Alliance"
🇷🇺
Kirovsk, Leningradskaya Region, Russian Federation
Azienda Ospedaliero Universitaria di Parma
🇮🇹
Parma, Italy
Cardiological Dispensary
🇷🇺
Ivanovo, Russian Federation
4th Wojskowy Szpital Kliniczny z Poliklinika, Klinika Kardiologii
🇵🇱
Wroclaw, Dolnoslaskie, Poland
Hospital Central de Asturias
🇪🇸
Oviedo, Asturias, Spain
A.R.N.A.S. Civico G. Di Cristina Benfratelli
🇮🇹
Palermo, Italy
Assaf Harofeh Medical Centre
🇮🇱
Beer Yahkov, Israel
City Clinical Hospital #15 named after O.M. Filatov
🇷🇺
Moscow, Russian Federation
Hospital Vall d´Hebrón
🇪🇸
Barcelona, Spain
Szpital Uniwersytecki w Krakowie
🇵🇱
Kraków, Malopolskie, Poland
SPZOZ, Szpital Wojewódzki we Wloclawku
🇵🇱
Kujawsko-pomorskie, Poland
Research Institute for Complex Issues of Cardiovascular Diseases
🇷🇺
Kemerovo, Russian Federation
Azienda Ospedaliera S. Sebastiano di Caserta
🇮🇹
Caserta, Italy
Hospital Clinic I Provincial de Barcelona
🇪🇸
Barcelona, Spain
Ural Institute of Cardiology
🇷🇺
Ekaterinburg, Russian Federation
Universitätsklinikum Heidelberg
🇩🇪
Heidelberg, Baden-Wuerttemberg, Germany
Sahlgrenska Universitetsjukhuset
🇸🇪
Göteborg, Sweden
City Clinical Hospital # 23 n.a."Medsantrud"
🇷🇺
Moscow, Russian Federation
Hospital Universitario Marques de Valdecilla
🇪🇸
Santander, Spain
Freeman Hospital
🇬🇧
Newcastle Upon Tyne, England, United Kingdom
Hospital Clinico Universitario de Valencia
🇪🇸
Valencia, Spain
Altai Regional Cardiological Dispensary
🇷🇺
Barnaul, Russian Federation
Regional Clinical Hospital
🇷🇺
Krasnoyarsk, Russian Federation
Royal Victoria Hospital
🇬🇧
Northern Ireland, United Kingdom
Saint Richards Hospital
🇬🇧
West Sussex, England, United Kingdom
Uppsala University Hospital
🇸🇪
Uppsala, Sweden
Royal Sussex County Hospital
🇬🇧
Brighton, England, United Kingdom
Tufts Medical Center
🇺🇸
Boston, Massachusetts, United States
Indiana Heart Physicians, Inc.
🇺🇸
Indianapolis, Indiana, United States
Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie
🇵🇱
Warszawa, Mazowieckie, Poland
TweeSteden Ziekenhuis
🇳🇱
Tilburg, Noord-brabant, Netherlands
Academisch Medisch Centrum
🇳🇱
Amsterdam, Noord-holland, Netherlands
Maasstad Ziekenhuis
🇳🇱
Rotterdam, Zuid-holland, Netherlands
Ziekenhuis Rijnstate Arnhem
🇳🇱
Gelderland, Netherlands
Veterans Affairs Medical Center, Duke University Medical Center
🇺🇸
Durham, North Carolina, United States
San Antonio Endovascular and Heart Institute
🇺🇸
San Antonio, Texas, United States
Azienda Ospedaliero-Universitaria Careggi
🇮🇹
Firenze, Italy
Azienda Ospedaliera Universitaria San Martino
🇮🇹
Genova, Italy
Ospedale Civile SS Annunziata ASL 1
🇮🇹
Sassari, Italy
Karlstad Central Hospital
🇸🇪
Karlstad, Sweden
Institut Universitaire de Cardiologie et de Pneumologie de Québec
🇨🇦
Quebec City, Quebec, Canada
Montreal Heart Institute
🇨🇦
Montréal, Quebec, Canada
Hôpital du Sacré-Coeur de Montréal
🇨🇦
Montréal, Quebec, Canada
Allgemeines Krankenhaus der Stadt Linz
🇦🇹
Linz, Upper Austria, Austria
University of Florida
🇺🇸
Gainesville, Florida, United States
Ashford and Saint Peter's Hospital NHS Trust
🇬🇧
Surrey, England, United Kingdom
Fakultní nemocnice u sv. Anny v Brne
🇨🇿
Brno, Czech Republic
Minneapolis Heart Institute
🇺🇸
Minneapolis, Minnesota, United States
New Brunswick Heart Centre
🇨🇦
Saint John, New Brunswick, Canada
Medizinische Universität Wien
🇦🇹
Wien, Vienna, Austria
The James Cook University Hospital
🇬🇧
Middlesbrough, England, United Kingdom
City Clinical Hospital #5
🇷🇺
Nizhni Novgorod, Russian Federation
Penza Regional Clinical Hospital n.a. N.N. Burdenko
🇷🇺
Penza, Russian Federation
Sheba Medical Center
🇮🇱
Tel Hashomer, Israel
ZIV Medical Center
🇮🇱
Zafed, Israel
Meir Medical Center
🇮🇱
Kfar Saba, Israel
Veterans Affairs San Diego Healthcare System
🇺🇸
San Diego, California, United States
Spectrum Clinical Research Institute, Inc
🇺🇸
Moreno Valley, California, United States
John Muir Medical Center Concord Campus
🇺🇸
Walnut Creek, California, United States
Washington Hospital Center
🇺🇸
Washington, District of Columbia, United States
Cardiology Research Associates
🇺🇸
Daytona Beach, Florida, United States
Jacksonville Heart Center
🇺🇸
Jacksonville, Florida, United States
Mount Sinai Medical Center
🇺🇸
Miami Beach, Florida, United States
Mayo Clinic Jacksonville
🇺🇸
Jacksonville, Florida, United States
Gateway Cardiology, PC
🇺🇸
Saint Louis, Missouri, United States
Iowa Heart Center
🇺🇸
West De Moines, Iowa, United States
The Indiana Heart Hospital
🇺🇸
Indianapolis, Indiana, United States
Northwest Indiana Cardiovascular Physicians
🇺🇸
Valparaiso, Indiana, United States
Saint Joseph Cardiology Associates
🇺🇸
Lexington, Kentucky, United States
Northeast Cardiology Associates
🇺🇸
Bangor, Maine, United States
Clinical Trials of America, Inc.
🇺🇸
Shreveport, Louisiana, United States
Baltimore Heart Associates
🇺🇸
Baltimore, Maryland, United States
Cape Cod Research Institute
🇺🇸
Hyannis, Massachusetts, United States
Oakwood Hospital and Medical Center
🇺🇸
Dearborn, Michigan, United States
Essentia Health
🇺🇸
Duluth, Minnesota, United States
Saint Cloud Hospital
🇺🇸
Saint Cloud, Minnesota, United States
Cardiology Associates of North Mississippi
🇺🇸
Tupelo, Mississippi, United States
Saint John's Regional Medical Center
🇺🇸
Springfield, Missouri, United States
Dartmouth Hitchcock Medical Center
🇺🇸
Lebanon, New Hampshire, United States
Buffalo Heart Group
🇺🇸
Buffalo, New York, United States
SJH Cardiology Associates
🇺🇸
Liverpool, New York, United States
Columbia University Medical Center
🇺🇸
New York, New York, United States
Hudson Valley Heart Center
🇺🇸
Poughkeepsie, New York, United States
Central Bucks Cardiology
🇺🇸
Doylestown, Pennsylvania, United States
Mid Carolina Cardiology
🇺🇸
Charlotte, North Carolina, United States
Ohio Health Research Institute
🇺🇸
Columbus, Ohio, United States
Saint Vincent Health Care Center
🇺🇸
Erie, Pennsylvania, United States
The Heart and Vascular Center
🇺🇸
Beaver, Pennsylvania, United States
North Texas Healthcare System, Dept. of Veteran's Affairs
🇺🇸
Dallas, Texas, United States
Research Associates of Jackson
🇺🇸
Jackson, Tennessee, United States
Gamma Medical Research Inc.
🇺🇸
Mission, Texas, United States
Victoria Heart and Vascular Center
🇺🇸
Victoria, Texas, United States
Sentara Cardiovascular Research Institute
🇺🇸
Norfolk, Virginia, United States
Landeskrankenhaus Graz West
🇦🇹
Graz, Styria, Austria
Landesklinikum Sankt Pölten
🇦🇹
Saint Pölten, Lower Austria, Austria
Wilhelminenspital der Stadt Wien
🇦🇹
Wien, Vienna, Austria
Ziekenhuis Netwerk Antwerpen Middelheim
🇧🇪
Antwerp, Antwerpen, Belgium
Centre Hospitalier Universitaire Sart Tilman Liège
🇧🇪
Liege, Belgium
Hamilton Health Sciences
🇨🇦
Hamilton, Ontario, Canada
Scarborough Cardiology Research Associates
🇨🇦
Scarborough, Ontario, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
🇨🇦
Montreal, Quebec, Canada
HaEmek Medical Center
🇮🇱
Afula, Israel
Všeobecná fakultní nemocnice v Praze
🇨🇿
Praha, Czech Republic
Fakultní Nemocnice v Motole
🇨🇿
Praha, Czech Republic
Hôpital Rangueil
🇫🇷
Toulouse Cedex 9, Midi-Pyrenees, France
Sankt Johannes Hospital
🇩🇪
Dortmund, Nordrhein-westfalen, Germany
Groupe hospitalier La Pitié Salpêtrière
🇫🇷
Paris, France
Kliniken Maria Hilf GmbH
🇩🇪
Mönchengladbach, Nordrhein-westfalen, Germany
Asklepios-Kliniken Langen
🇩🇪
Langen, Hessen, Germany
Städtische Kliniken Bielefeld gGmbH
🇩🇪
Bielefeld, Nordrhein-westfalen, Germany
Vivantes Klinikum im Friedrichshain
🇩🇪
Berlin, Germany
Rambam Medical Center
🇮🇱
Haifa, Israel
Krankenhaus Der Barmherzigen Brüder Trier
🇩🇪
Trier, Rheinland-pfalz, Germany
Barzilai Medical Center
🇮🇱
Ashkelon, Israel
Bnai Zion Medical Center
🇮🇱
Haifa, Israel
Tel Aviv Souraski Medical Center
🇮🇱
Tel Aviv, Israel
Shaare Zedek Medical Center
🇮🇱
Jerusalem, Israel
Western Galilee Hospital
🇮🇱
Nahariya, Israel
Hillel Yaffe Medical Center
🇮🇱
Ramat Gan, Israel
Catharina Ziekenhuis
🇳🇱
Eindhoven, Noord-brabant, Netherlands
SPZOZ, SPSK nr 7 Slaskiego Uniwersytetu Medycznego w Katowicach, Górnoslaskie Centrum Medyczne
🇵🇱
Katowice, Slaskie, Poland
Samodzielny Publiczny Szpital Kliniczny nr. 1 im. Przemienienia Panskiego
🇵🇱
Poznan, Poland
Regional Clinical Hospital №3
🇷🇺
Chelyabinsk, Russian Federation
National Research Center For Preventive Medicine
🇷🇺
Moscow, Russian Federation
University Clinical Hospital #1
🇷🇺
Moscow, Russian Federation
City Clinical Emergency Hospital # 2
🇷🇺
Novosibirsk, Russian Federation
Scientific and Research Institution Of Cardiology
🇷🇺
Tomsk, Russian Federation
Hospital Universitario de Bellvitge
🇪🇸
L´Hospitalet de Llobregat, Barcelona, Spain
Hospital General Universitario de Alicante
🇪🇸
Alicante, Spain
Complejo Hospitalario Universitario de Vigo, Meixoeiro Hospital
🇪🇸
Vigo, Pontevedra, Spain
Hospital Clínico Universitario Virgen de la Victoria
🇪🇸
Malaga, Spain
Falu lasarett
🇸🇪
Falun, Sweden
University of Florida Health Sciences Center-Jacksonville
🇺🇸
Jacksonville, Florida, United States
Michigan Heart, PC
🇺🇸
Hialeah, Florida, United States
Heart Center Research, LLC
🇺🇸
Huntsville, Alabama, United States
Saint Elizabeth's Medical Center
🇺🇸
Boston, Massachusetts, United States
Cardiovascular Institute of Northwest Florida
🇺🇸
Panama City, Florida, United States
Carolina Cardiology Associates
🇺🇸
High Point, North Carolina, United States
University of California San Diego
🇺🇸
La Jolla, California, United States
Zasa Clinical Research
🇺🇸
Atlantis, Florida, United States
Scottsdale Healthcare
🇺🇸
Scottsdale, Arizona, United States
South Denver Cardiology Associates, PC
🇺🇸
Littleton, Colorado, United States
Westchester Medical Center
🇺🇸
Valhalla, New York, United States
East Coast Institute for Research
🇺🇸
Jacksonville, Florida, United States
Cardiology Associates of Southeast Ohio, Inc.
🇺🇸
Zanesville, Ohio, United States
University of Chicago Medical Center
🇺🇸
Chicago, Illinois, United States
Federal Center of Heart, Blood and Endocrinology n.a. V.A.Almazov
🇷🇺
Saint-Petersburg, Russian Federation
Wake Heart Research
🇺🇸
Raleigh, North Carolina, United States
Buffalo Cardiology and Pulmonary Associates, PC
🇺🇸
Williamsville, New York, United States
Pinnacle Health System
🇺🇸
Wormleysburg, Pennsylvania, United States
Hadassah Ein-Kerem Medical Centre
🇮🇱
Jerusalem, Israel
Hospital Clínico San Carlos
🇪🇸
Madrid, Spain
Volgograd Regional Clinical Cardiological Center
🇷🇺
Volgograd, Russian Federation
Saint Michael's Hospital
🇨🇦
Toronto, Ontario, Canada
Centre Hospitalier Universitaire de Sherbrooke
🇨🇦
Sherbrooke, Quebec, Canada
Oklahoma City Veterans' Affairs Medical Center
🇺🇸
Oklahoma City, Oklahoma, United States
South Oklahoma Heart Research
🇺🇸
Oklahoma City, Oklahoma, United States
Centennial Heart Cardiovascular Consultants, LLC
🇺🇸
Nashville, Tennessee, United States
Cardiology, PC
🇺🇸
Birmingham, Alabama, United States
Pepin Heart Hospital and Dr. Kiran C. Patel Research Institute
🇺🇸
Tampa, Florida, United States
Yale University School of Medicine
🇺🇸
New Haven, Connecticut, United States
University of Alabama at Birmingham
🇺🇸
Birmingham, Alabama, United States
Florida Heart Institute
🇺🇸
Orlando, Florida, United States
Universitetssjukhuset Örebro
🇸🇪
Örebro, Orebro, Sweden
Rhode Island Hospital
🇺🇸
Providence, Rhode Island, United States