Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

Not Applicable

Completed

• Conditions: Duration of Hospitalization
• Interventions: Drug: Isoflurane; Drug: Sevoflurane

• Registration Number: NCT01379664
• Lead Sponsor: The Cleveland Clinic

Brief Summary

Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane.

The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-06-17
• Study First Submitted QC: 2011-06-21
• Study First Posted: 2011-06-23
• Study Start: 2011-07
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Results First Submitted: 2016-11-29
• Status Verified: 2017-02
• Results First Submitted QC: 2017-02-25
• Last Update Submitted: 2017-02-25
• Results First Posted: 2017-04-10
• Last Update Posted: 2017-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1584

Inclusion Criteria

• Must have surgery in G operating room suite

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Isoflurane	Isoflurane	Isoflurane is to be administered to patients in this arm during surgery
Sevoflurane	Sevoflurane	Sevoflurane is to be administered to patients in this arm during surgery

Primary Outcome Measures

Name	Time	Method
Hospital Length of Stay	participants will be followed for the duration of hospital stay, an expected average of 3 days

Secondary Outcome Measures

Name	Time	Method
Time-weighted Average Verbal Rating Pain Score	up to 72 hours after surgery	Time-weighted average VRS (Verbal Rating Scale) pain score over the first 72 h after surgery as recorded by nurses at approximately 4-h intervals. The VRS pain score is from 0 (no pain) to 10 (worst imaginable pain).
Total Intraoperative Opioid Consumption	intraoperative	Total amount of opioid in IV morphine equivalents used during surgeyr

Trial Locations

Locations (1)

Cleveland Clinic; 🇺🇸 Cleveland, Ohio, United States