Diffuse Optical Spectroscopy Measurement Technique is Helping Develop More Effective Diagnostic Tools and Therapeutic Regimes for Diabetes, Metabolic Syndrome and Other Mitochondrial Diseases Some Time in the Future
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Syndrome
- Sponsor
- University of California, Irvine
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- Near Infrared Spectroscopy to assess muscle mitochondrial OXPHOS function.
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
There has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus and the overlapping Metabolic Syndrome.
Detailed Description
Once the mitochondrial defect(s) of these subjects has been defined, the data will be used to develop two non-invasive screening tools to detect mitochondrial defects in Diabetes Mellitus and Metabolic Syndrome patients. The device call Diffuse Optical Spectroscopy develope at Beckman Laser Instituteis is non-invasive measurement technique, to measure the properties of the muscle tisuue and vascular activity (calf, bicep, or the brain)to evaluate the patient's metabolic status and and to assess muscle mitochondrial OXPHOS function.
Investigators
Beckman Laser Institute and Medical Center
Virginia Kimonis, MD, MRCP
University of California, Irvine
Eligibility Criteria
Inclusion Criteria
- •Chinese descent and have been clinically diagnosed with diabetes mellitus (DM) or have met the study criteria for metabolic syndrome (MS).
Exclusion Criteria
- •non chiness descent
Outcomes
Primary Outcomes
Near Infrared Spectroscopy to assess muscle mitochondrial OXPHOS function.
Time Frame: 4 weeks