Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort
- Conditions
- Metabolic SyndromeType 2 Diabetes Mellitus
- Interventions
- Device: Diffuse Optical Spectroscopy
- Registration Number
- NCT00786721
- Lead Sponsor
- University of California, Irvine
- Brief Summary
There has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus and the overlapping Metabolic Syndrome.
- Detailed Description
Once the mitochondrial defect(s) of these subjects has been defined, the data will be used to develop two non-invasive screening tools to detect mitochondrial defects in Diabetes Mellitus and Metabolic Syndrome patients.
The device call Diffuse Optical Spectroscopy develope at Beckman Laser Instituteis is non-invasive measurement technique, to measure the properties of the muscle tisuue and vascular activity (calf, bicep, or the brain)to evaluate the patient's metabolic status and and to assess muscle mitochondrial OXPHOS function.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 9
- Chinese descent and have been clinically diagnosed with diabetes mellitus (DM) or have met the study criteria for metabolic syndrome (MS).
- non chiness descent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Diffuse Optical Spectroscopy Diffuse Optical Spectroscopy muscle properties scanning
- Primary Outcome Measures
Name Time Method Near Infrared Spectroscopy to assess muscle mitochondrial OXPHOS function. 4 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beckman Laser Institute Medical clinic
🇺🇸Irvine, California, United States