Trans-nasal Humidified Rapid- Insufflation Ventilatory Exchange in Children Requiring Emergent Intubation (Kids THRIVE): A Randomised Controlled Trial.

Not Applicable

Completed

• Conditions: Airway Management; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12617000147381
• Lead Sponsor: Queensland Children's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-27
• Study Completion: 2022-10-24
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 961

Inclusion Criteria

* Is aged less than 16 years at the time of randomisation
* Requires rapid sequence induction (RSI) or modified RSI* for emergency intubation and ventilation in either the emergency department or intensive care unit

* Modified RSI is defined as the provision of ventilatory support by bag-mask ventilation, or other method, during the pre-oxygenation phase of induction of anaesthesia

Exclusion Criteria

* Planned endo-tracheal tube changes
* Requires immediate intubation for loss of cardiac output or respiratory arrest.
* Location of intubation is outside the Emergency Department or Intensive Care Unit.
* Blocked nasal airway due to anatomical abnormality (e.g. Choanal atresia)
* Blocked nasal airway due to acute injury, trauma or disease (e.g. Severe facial trauma)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hypoxia defined as oxygen saturations using pulse oximetry less than 90% or a decrease of 10% from pre-intubation oxygen saturation where 100% oxygen saturation can not be clinically achieved during pre-oxygenation.[ After induction of anaesthesia and prior to intubation in children];Proportion of successful first attempt intubations of success rate of intubation during emergency intubation. A single advanced airway manoeuvre beginning with the insertion of a device, such as a laryngoscope, into the patient’s mouth and ending when the device is removed from the patient’s mouth, or where there is a change in operator during the procedure even if the device is not removed.[ During emergency intubation]