The effects of sodium pentaborate (NaB) supplementation on calculi status and related metabolic risk factors in patient with kidney stone
Not Applicable
- Conditions
- kidney stone.Calculus of kidney and ureter
- Registration Number
- IRCT20090609002017N34
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Men and women aged 20-50 years
Patients with kidney stones with urologist diagnosis (other than obstructive, infectious, and ureter stones)
Patients with kidney stones who, can be follow with drug therapy for a maximum of 3 month,according to a urologist diagnosis
Not suffering from liver and kidney failure
Patients who are willing to participate in the study
Exclusion Criteria
Pregnancy or lactation
Suffering from other kidney related metabolic disorders and disease, at the same time
Smoking
Having a special diet
Patients with obstructive stones, infections, and ureter stones and Emergency cases requiring special treatment or surgery with the diagnosis of urologists
Changes in the drug protocol during the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Calculi status. Timepoint: Weeks 0, 4 and 8 study. Method of measurement: Ultra sonography.;Values of kidney functional tests (Urea, Creatinin, BUN, Uric acid, Analysis of urinary ions (Ca, k, Na), Serum PTH). Timepoint: Before and after treatment. Method of measurement: Enzymatic methods, Atomic absorption, ELISA kit.;Status of metabolic syndrome. Timepoint: Before and after treatment. Method of measurement: Measurement of blood pressure with stethoscope, Measurement of waist circumference , Measurement of HDL-cholesterol, triglyceride, FBS and fasting Insulin through enzymatic methods.
- Secondary Outcome Measures
Name Time Method Values of liver functional tests (ALT_AST_ALP). Timepoint: Before and after treatment. Method of measurement: Enzymatic methods.;Urine culture status. Timepoint: Before and after treatment. Method of measurement: Standard methods.;Dietary status (Dietary intake and Appetite). Timepoint: Before and after treatment. Method of measurement: FFQ and VAS questionnaires.;Serum levels of oxidative Stress indices (Malondialdehyde (MDA) and Total antioxidant capacity). Timepoint: Before and after treatment. Method of measurement: Spectrophotometry.;Status of some blood indices [PT(prothrombin time), ESR (erythrocyte sedimentation rate), INR (International Normalized Ratio), Albumin]. Timepoint: Before and after treatment. Method of measurement: Standard method, Westergren, Calculate, ELISA kit.