Bowditch Revisited: Defining the Optimum Heart Rate Range in Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 入组人数
- 110
- 试验地点
- 2
- 主要终点
- Change in Exercise Time
研究概览
简要总结
The investigators are examining the relationship between heart rate and heart contraction in patients with heart failure and pacemakers, aiming to improve quality of life.
详细描述
Heart rate lowering is a cornerstone of the management of chronic heart failure (CHF) and the degree of lowering is closely related to improvements in longevity, hospitalisation rate and heart function. The investigators have shown that increasing heart rates using pacemakers does not increase exercise capacity in CHF patients. This might be because the optimal heart rate range for contraction is narrower for patients with CHF. At higher heart rates, heart contraction might be less strong. The investigators now want to examine the relationship between heart rate and heart contraction in patients with heart failure and pacemakers. Tailored pacemaker heart rate setting's, individually optimised for heart contractility as assessed by cardiac ultrasound, will be investigated to examine the effects on exercise tolerance .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable CHF
- •Cardiac Resynchronisation Therapy (CRT) device for >3 months,
- •able to walk on treadmill
排除标准
- •unable to walk on treadmill,
- •unstable angina pectoris
- •uncontrolled heart rate
- •prescribed calcium channel blocker
- •significant aortic stenosis
- •significant airways disease
结局指标
主要结局
Change in Exercise Time
时间窗: Assessed following the second treadmill test, 1 week later
Exercise duration in seconds
次要结局
- Change in Peak Oxygen Consumption (pVO2)(Assessed following the second treadmill test, 1 week later)
研究者
John Gierula
NIHR Fellow and Cardiac Physiologist
University of Leeds