A PROSPECTIVE OBSERVATIONAL STUDY ON SERUM LDH AND URIC ACID LEVELS IN HYPERTENSIVE DISORDERS OF PREGNANCY AND PREDICTION OF FETOMATERNAL OUTCOME
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- To predict the feto - maternal outcome in relation to abnormal serum levels of LDH and URIC ACID in pregnant woman with hypertensive disorders of pregnancy, outcomes post delivery such as morbidity , mode of delivery , nice admission of the baby and over all well being and early discharge from the hospital
研究概览
简要总结
Pregnancy-related hypertensive disorders occur in 3-5% of pregnancies significantly contributing to maternal morbidity and mortality
·Assessing a range of biochemical and biophysical indicators in the initial stages of pregnancy plays a crucial role in anticipating the occurrence of adverse outcome. Efforts have been undertaken to co-relate these early markers with hypertensive disorders of pregnancy associated colmplications and flawed placentation, compromised blood flow, and dysfunction of endothelial cells.
·Elevated uric acid levels is an early marker associated with hypertensive disorders of pregnancy and is detected as early as 10 weeks of gestation
•Increased levels of uric acid suggests serious impending damage to kidney function. While elevated concentrations of these markers are not uniformly seen in every woman with preeclampsia, they do appear toidentify a subset of preeclamptic women who are at greater risk for maternal and fetal morbidities, thereby suggesting diagnostic and also prognostic significance.
•Lactate dehydrogenase (LDH) is an intracellular enzyme; thus, elevated levels are indicative of cellular dysfunction, hemolysis, and cell death.Hypoxia in preeclampsia increases both glycolysis and LDH activity, resulting in higher lactate production
Studies have shown an increased serum levels of LDH as a predictive factor in the onset of hemolysis, elevated liver enzyme levels, and low platelet levels (HELLP syndrome) and small for gestational age babies
NEED FOR THE STUDY:
•Maternal mortality is global indicator of National health index.
•Early detection and timely intervention in cases of hypertensive disorders of pregnancy can decrease maternal mortality significantly which precisely is the main objective of the study
•Another objective being determining fetal outcomes, the study helps in closely monitoring pregnant women which leads to better fetal outcomes, hence achieving safe confinement.
•There are no ethical issues associated with the study
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- Female
入选标准
- •Pregnant women with period of gestational age 20 weeks with singleton pregnancy with hypertensive disorders of pregnancy.
排除标准
- •History of medical disorders like cardiac, renal, hemolytic and liver diseases hyperurecimia and gout Patients who refused to take part as per our protocol Any medical or surgical disorders with deranged RFT & LFT.
结局指标
主要结局
To predict the feto - maternal outcome in relation to abnormal serum levels of LDH and URIC ACID in pregnant woman with hypertensive disorders of pregnancy, outcomes post delivery such as morbidity , mode of delivery , nice admission of the baby and over all well being and early discharge from the hospital
时间窗: 48 hours post delivery
次要结局
- Preventative care & prophylactic treatment can be given to patients in her better results in future pregnancy(2 days after delivery)
研究者
KAVYA BASANAGOUDA NAGANAGOUDAR
SHRI B M PATIL MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE