PFC-HC coupling in schizophrenia and related polymorphisms in working memory
- Conditions
- F20.0Paranoid schizophrenia
- Registration Number
- DRKS00004290
- Lead Sponsor
- Zentralinstitut für Seelische Gesundheit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 220
All subjects:
•Adequate proficiency in German language
•Ability to understand the study protocol and give informed consent
For patients:
•Subjects have to meet DSM-IV criteria for schizophrenia
•Stable monotherapy or unmedicated patients, infrequent use of benzodiazepines is allowed (last use >24 hours before study to avoid influence on cognitive functions)
•subjects with a psychiatric condition (healthy controls), acute worsening of symptoms or additional psychiatric condition (patients)
•presentation with a severe neurological disorder
•major medical conditions e.g. renal failure, hepatic cirrhosis
•pregnancy
•metal implants
•tatoos covering head or neck
•claustrophobia
•substance abuse (excluding nicotine and caffeine)
•arterial hypertension
•diabetes
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •Characterization of task-related BOLD activation in healthy subjects and patients using both univariate (statistical parametric mapping) and multivariate methods („machine learning). <br><br>•Evaluation of prefrontal-hippocampal connectivity during working memory processes.<br>•Modulation of both activity and connectivity patterns by psychiatric risk polymorphisms.<br><br>
- Secondary Outcome Measures
Name Time Method •Comparison of imaging data with biophysical models (cooperation with Prof. Dr. Daniel Durstewitz) to gain a better mechanistic understanding of underlying (patho)physiological processes<br>•Development of multivariate statistical methods that can be used with functional imaging data<br>•Correlation of neuropsychological and imaging data<br><br>