Cardio protective effect of dexmedetomidine in CABG

Phase 2

• Conditions: myocardial injury.; Other functional disturbances following cardiac surgery

• Registration Number: IRCT2016071113456N6
• Lead Sponsor: Vice chancellor for research of Guilan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Isolated and elective CABG surgery; Age 35 to 65 years old;3 or 4 coronary artery stenosis; EF>45%;Normal sinus rhythm and normal heart rate; myocardial enzymes troponin and CK-MB levels before surgery in normal range; Exclusion criteria:Heart Rate<50; SBP<90 mmHg;Thyroid dysfunction
uncontrolled diabetes; History of corticosteroid therapy; addiction

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evels of CK-MB. Timepoint: Before anesthesia(T0); 6 hr post surgery(T1); 12 hrs post surgery (T2) ; 24 hrs post surgery (T3) ;48 hrs post surgery (T4). Method of measurement: Immunoassay.;Serum Cortisol level. Timepoint: Before anesthesia(T0); 6 hr post surgery(T1); 12 hrs post surgery (T2) ; 24 hrs post surgery (T3) ;48 hrs post surgery (T4). Method of measurement: Immunoassay.

Secondary Outcome Measures

Name	Time	Method
Serum levels of Troponin I. Timepoint: Before anesthesia(T0); 6 hr post surgery(T1); 12 hrs post surgery (T2) ; 24 hrs post surgery (T3) ;48 hrs post surgery (T4). Method of measurement: immunoassay.