Effect of Liraglutide on metabolism and function of the left ventricle in patients with type 2 diabetes and heart problems: study with RMN investigations

• Conditions: patients affected by type 2 diabetes and heart failure; MedDRA version: 14.1Level: HLTClassification code 10012654Term: Diabetic complications cardiovascularSystem Organ Class: 10014698 - Endocrine disorders; Therapeutic area: Diseases [C] - Nutritional and Metabolic Diseases [C18]

• Registration Number: EUCTR2011-001408-37-IT
• Lead Sponsor: FONDAZIONE CENTRO S. RAFFAELE DEL MONTE TABOR

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04-10
• Last Update Posted: 27 January 2014

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

- Age between 40-70 years - men with type 2 diabetes for at least 1 year - HbA1c> 7% but less than 10% for at least the last 6 months during treatment with metformin 2 g / day - Ejection Fraction <50% but not more than 25%
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 20
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 10

Exclusion Criteria

- Body mass index> 32 kg/m2 - autonomic neuropathy - Creatinine> 1.5 mg / dl - Any disease / condition that might interfere with the study - Unstable Angina - Arrhythmia - Patients on metabolic treatment (trimetazidine, acipimox, perhexeline, thyroid hormones) - Patients unable to attend the study or to undergo testing protocol (contraindications to MRI such as pacemakers, metal objects and non-removable) - Claustrophobia - Anterior myocardial infarction

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified