// Safety and Efficacy of early switch to oral antibiotic in patients with biliary bacteremia: multicenter, randomized, open label study
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0000601
- Lead Sponsor
- Chung-Ang University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 166
The patients whose age are between 20 and 85, who visited three hospitals including Chung-Ang university hospital since 2010.9, where ciprofloxacin-susceptible gram negative rods were detected on blood stream and receiving biliary decompression due to biliary infection.
Patients were randomized by 1:1 into two groups.
(1) Absoulute neutrophil count < 500
(2) On applying immunosuppressive agents or having malignancy
(3) Severe infection where BP-intensifing agents or mechanical ventilation would be need
(4) Receiving biliary decompression within 2 weeks
(5) Severe infection in other organs
(6) Other pre-existing hepatobiliary infections or their complications
such as liver abscess
(7) Other additional intravenous antibiotics applied during the study period.
(8) History of cholecystectomy or hepatectomy/lobectomy of liver
(9) study drop-out
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Eradication rate of bacteria at 30-days after diagnosis of bacteremia
- Secondary Outcome Measures
Name Time Method Re-infection rate