A Randomised Control Trial Using Oral Antibiotics Following a Short Course of Intravenous Therapy in Children with Acute Osteomyelitis with or without Septic Arthritis

Recruiting

• Conditions: Osteomyelitis in the paediatric population in New Zealand; Infection - Studies of infection and infectious agents; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12609000459224
• Lead Sponsor: Diana Lennon

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-06-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Children who presented with a diagnosis of actute osteomyelitis with or without septic arthritis.
Osteomyelitis is defined as an acute disease with symptoms, clinical or radiological signs compatible with the disease, and with or without positive microbiology from a local bony lesion or blood culture.
Septic arthritis is defined by an acute disease with positive inflammatory or microbiology result in a joint aspirate.

Exclusion Criteria

1) Chronic osteomyelitis
2) Vertebral osteomyelitis
3) Atypical causative organism including gram negative bacteria and resistant organisms
4) Children with a history of compound fracture or penetrating injury
5) Immunodeficiency
6) Multifocal disease
7) Failure to achieve defervescence within 10-14 days from initiation of intravenous antibiotics
8) Children unable to take oral antibiotics
9) History of penicillin anaphylaxis

Study & Design

• Study Type: Interventional
• Study Design: Not specified