The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy

Not Applicable

Completed

• Conditions: Skin and Subcutaneous Tissue Infection
• Interventions: Procedure: IV-to-PO conversion of antibiotics

• Registration Number: NCT04781439
• Lead Sponsor: Gia Dinh People Hospital

Brief Summary

To date, many studies showed the great benefits of switching from IV to PO antibiotics in some infectious diseases, especially skin and soft tissue, urinary tract, respiratory tract, gallbladder, and biliary tract infection. Higher level of evidence is necessary to confirm the benefit of early switching protocol in infectious condition management. Therefore, we conducted a clinical trial to investigate the effectiveness and cost of IV-to-PO antibiotic switch therapy in some surgical infection conditions.

Detailed Description

Introduction: The benefit of early switching from intravenous (IV) to oral (PO)was raising from the last decade. This randomized clinical trial was to evaluate the effect of early switching from IV to PO antibiotics on the outcome of surgical patients at a public hospital.

Methods: Patients admitted for a therapeutic antibiotic to orthopedic and general surgery conditions were randomly assigned to three groups: control (non-switching), early switching (within 48-72 hours), and late switching (after 72 hours). The rate of effectiveness of each arm, length of hospital stay, length of IV antibiotics, and cost were recorded prospectively.

Study Timeline

• Study Start: 2020-03-01
• Primary Completion: 2020-08-30
• Study Completion: 2020-09-29
• Status Verified: 2021-03
• Study First Submitted: 2021-03-02
• Study First Submitted QC: 2021-03-03
• Last Update Submitted: 2021-03-03
• Study First Posted: 2021-03-04
• Last Update Posted: 2021-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

• on the second day of IV antibiotic
• no difficulties on taking oral medication
• clinical improvement

Exclusion Criteria

• n/a

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IV-to-PO conversion after 72 hours	IV-to-PO conversion of antibiotics	late switching
IV-to-PO conversion within 48-72 hours	IV-to-PO conversion of antibiotics	early switching

Primary Outcome Measures

Name	Time	Method
rate of effectiveness	3 months	rate of effectiveness of the infection treatment

Secondary Outcome Measures

Name	Time	Method
length of IV antibiotics	3 months	length of IV antibiotics usage
length of hospital stay	3 months	length of hospital stay after starting the antibiotic treatment
cost of treatment	3 months	cost of antibiotics

Trial Locations

Locations (1)

Gia Dinh people hospital; 🇻🇳 Ho Chi Minh City, Vietnam