Congenital Syphilis at Third-level Pediatric Hospital. A Prospective Cohort With Retrospective Evaluation Study of the Last Three Decades.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- Analyze the number of cases of congenital syphilis according to the years surveyed at the Ricardo Gutierrez Children's Hospital
Study Overview
Brief Summary
Syphilis is an infectious disease caused by Treponema pallidum. In children, there are two different forms of this disease; acquired syphilis and congenital syphilis, which results from transplacental transmission of spirochetes.
The worldwide incidence of congenital syphilis has increased in past years, probably due to inadequate control of pregnant women and lack of early diagnose and treatment in acute infected adults.
This infection can have numerous and non-specific manifestations at all stages, and may simulate other diseases, which can delay diagnose if not suspected.
A high number of newborns can be asymptomatic, so diagnose is confirmed or discharged by serologic testing after 6 to 10 months of age.
This study will observe the clinical presentation and the laboratory of patients with CS treated.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 0 Days to 1 Year (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Infants with reactive VDRL /RPR of mothers with positive serology without confirmed treatment or incomplete.
- •Patients with compatible clinical signs of syphils.
Exclusion Criteria
- •Patients with diagnosis of acquired syphilis
- •Patients whose medical records are missing
Outcomes
Primary Outcomes
Analyze the number of cases of congenital syphilis according to the years surveyed at the Ricardo Gutierrez Children's Hospital
Time Frame: Past 30 years
By examining clinical records we will describe prevalence of congenital syphilis through last 30 years.
Secondary Outcomes
- Describe the clinical presentation -symptoms and image findings - in children diagnosed with CS. Symptoms will be measured as present or not and described.(Past 30 years)
Investigators
Dr Jaime Altcheh
Principal Investigator
Hospital de Niños R. Gutierrez de Buenos Aires