Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

Not Applicable

Completed

• Conditions: Appetite; Faba Bean; Satiety Hormones; Post-prandial Blood Glucose; Insulin

• Registration Number: NCT02666586
• Lead Sponsor: University of Manitoba

Brief Summary

To describe the effect and mechanisms of action faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years).

Detailed Description

The overall objective is to describe the effect and mechanisms of action of faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years). The specific objectives are to test the acute effects of different faba bean ingredient smoothie on: 1) post-prandial blood glucose, appetite, satiety hormone and insulin for 200 minutes, and 2) food intake 120 minutes following consumption of the faba bean smoothie. Two short-term acute studies will be conducted to meet these objectives. Both acute studies will follow a randomized, double blinded, balanced, repeated measures design and the same protocol; except one will have an ad libitum pizza meal (study 1), while the other will have a fixed pizza meal (study 2) at 120 minutes. Half the participants will have blood drawn by IV and the other half will be finger prick.

Study Timeline

• Study First Submitted: 2015-11-19
• Study Start: 2016-01
• Study First Submitted QC: 2016-01-25
• Study First Posted: 2016-01-28
• Primary Completion: 2017-10-21
• Study Completion: 2017-10-21
• Status Verified: 2021-04
• Last Update Submitted: 2023-01-19
• Last Update Posted: 2023-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• healthy
• non-smoking males
• aged 20-30 years (min/max age)
• a body mass index between 20 and 25 kg/m2 (the range generally accepted as ideal/healthy by Health and Welfare Canada)

Exclusion Criteria

• individuals diagnosed with diabetes
• those on medication
• breakfast skippers
• on an energy restricted diet
• this study excludes females because appetite and blood glucose during the female menstruation cycle changes due to fluctuations in hormones

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
blood glucose	0-200 minutes	measured by finger prick blood samples by glucose meters

Secondary Outcome Measures

Name	Time	Method
physical comfort	0-200 minutes	measured by VAS questionnaire
appetite	0-200 minutes	measured by VAS questionnaire
energy/fatigue	0-200 minutes	measured by VAS questionaire
satiety hormones	0- 200mins	measured by enzyme-linked immunosorbent assay (ELISA)
food intake	120 minutes following consumption of the faba bean smoothie	energy intake at ad-libitum pizza meal
insulin	0-200mins	measured by ELISA

Trial Locations

Locations (1)

Richardson Centre for Functional Foods and Nutraceuticals; 🇨🇦 Winnipeg, Manitoba, Canada