Cardiovascular Effects of Sporting Events
- Conditions
- Coronary Heart Disease
- Interventions
- Behavioral: No exposure to sporting eventsBehavioral: Exposure to sporting events
- Registration Number
- NCT00795405
- Lead Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Brief Summary
Major sporting events may have adverse cardiovascular effects in subjects with coronary heart disease. We also hypothesized that the adverse cardiovascular effects of sporting events are a result of psychobiological processes including stress-induced hemodynamic changes, autonomic dysfunction and parasympathetic withdrawal, and inflammatory and prothrombotic responses, all of which may in turn promote myocardial ischemia.
- Detailed Description
Observational studies suggest that exposure to sporting events may worsen symptoms of angina and trigger acute myocardial infarction. The mechanisms for this association are unknown. To date, there have been no controlled exposures in patients with coronary heart disease: an important population who may be particularly susceptible to the adverse cardiovascular effects of sporting events.
In a randomized crossover controlled study, 38 patients with prior myocardial infarction will be exposed to sporting events or not. Myocardial ischemia will be quantified by ST-segment analysis using continuous 12-lead electrocardiography, and blood pressure change will be analyzed using ambulatory blood pressure monitoring. Autonomic function will be assessed by heart rate variability. Ischemic, inflammatory and prothrombotic markers will also be measured.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 38
- Previous myocardial infarction (>6 months previously)treated by coronary revascularization
- On standard secondary preventative therapy
- Angina pectoris (Canadian Cardiovascular Society grade ≥2)
- History of arrhythmia
- Uncontrolled hypertension
- Unstable coronary disease (acute coronary syndrome or unstable symptoms within 3 months)
- Occupational exposure to sporting events
- Diabetes
- Hepatic or renal failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 1 No exposure to sporting events No exposure to sporting events 2 Exposure to sporting events Exposure to sporting events
- Primary Outcome Measures
Name Time Method Evidence of definite myocardial ischemia confirmed by Holter monitoring 2 months Blood pressure measured by ambulatory blood pressure monitoring 2 months Heart rate variability 2 months
- Secondary Outcome Measures
Name Time Method Episode of angina 3 months Episode of neurological events 3 months Episode of arrhythmia 3 months