NCT00200252已完成4 期
Intramuscular Versus Intravascular Oxytocin for the Third Stage of Labour
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- change in hematocrit
研究概览
简要总结
Mothers are given the medication oxytocin after birth to help the uterus (womb) contract and therefore reduce blood loss. In Canada, oxytocin is given either into the muscle of the thigh or into a vein. However, it is not known which route is better.This study will test which dose and route of oxytocin is best in reducing blood loss following vaginal delivery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women 19 years and older
- •singleton pregnancy
- •32 weeks gestation
- •spontaneous vaginal delivery
排除标准
- •previous postpartum hemorrhage
- •placenta previa
- •grand multiparity (>4)
- •anticoagulation therapy
- •delivery prior to 32 weeks gestation
- •operative vaginal delivery
- •antepartum hemorrhage > 20 weeks
- •hemoglobin <10g/dL
- •multiple gestation
- •intrauterine death
研究组 & 干预措施
group B
Active Comparator
women in group B will receive 10 uts oxytocin IM
干预措施: oxytocin (Drug)
group C
Active Comparator
women in group C will receive oxytocin 5 uts IV
干预措施: oxytocin (Drug)
group A
Active Comparator
women in group A will receive oxytocin 5 uts IM
干预措施: oxytocin (Drug)
结局指标
主要结局
change in hematocrit
次要结局
- estimated blood loss
- postpartum hemorrhage (estimated blood loss > 500cc)
- severe postpartum hemorrhage (estimated blood loss > 1000cc)
- incidence of hypotension
- length of third stage of labour
- need for blood transfusion
- incidence of retained placenta
- need for dilatation and curettage
- need for hysterectomy
- need for additional oxytocics after delivery
- postpartum antibiotic use
- maternal satisfaction
- bleeding needing readmission
研究者
研究点 (1)
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