Effects of bromelain and serrapeptase supplementation on surgical and traumatic wound healing and pain reductio

Not Applicable

• Conditions: trauma.; Acute pain due to trauma; G89.11

• Registration Number: IRCT20140804018677N6
• Lead Sponsor: Research and technology deputy, Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2021

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Male and non-pregnant female
age>18y
Up to 1 week post trauma or surgery
Wound size between 1-10 cm
tend to use this supplement

Exclusion Criteria

Allergy to bromelain and serrapeptase
Collagen Vascular or autoimmune Diseases
mild-moderate and severe wound according to American infectious disease society criteria
Using steroidal drugs in 2 months prior to study (exp. inhaled steroidal drugs for COPD and asthma and topical steroidal medication
Using antibiotics in a week prior to study
radiation therapy of wound
HBA1c>10
venous insuf?ciency or osteomyelitis
Using immunosuppressant
active malignancies
Renal disorders ((blood urea nitrogen < 21.4 mmol/l, creatinine < 247.5 umol/l) or liver failure
MI in 3 months prior to study
Drug or alcohol abuse

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain of wound (trauma or surgical). Timepoint: Baseline and at the end of the study. Method of measurement: VAS (visual analog scale).;Size of wound (trauma or surgical). Timepoint: Baseline and at the end of the study. Method of measurement: Centimeter.