Digestive Tract Reconstruction After Gastrectomy of Gastric Cancer With Type 2 Diabetes

• Conditions: Gastric Cancer
• Interventions: Procedure: digestive tract reconstruction

• Registration Number: NCT01637350
• Lead Sponsor: Tianjin Medical University Cancer Institute and Hospital

Brief Summary

Different digestive tract reconstruction will affect the blood glucose level of gastric cancer with type 2 diabetes. Subtotal gastrectomy with Billroth II reconstruction and total gastrectomy with Roux-en-Y reconstruction may help to improve glycaemic control which includes fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of gastric cancer patients with type 2 diabetes.

Detailed Description

Different digestive tract reconstruction will affect the blood glucose level of gastric cancer with type 2 diabetes. Subtotal gastrectomy with Billroth II reconstruction and total gastrectomy with Roux-en-Y reconstruction may help to improve glycaemic control which includes fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of gastric cancer patients with type 2 diabetes.

The investigators will observed fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of the patients preoperation, 14 days postoperation 3 month and 6month postoperation. The investigators will observed the effect of blood glucose to different digestive tract reconstruction after gastrectomy of gastric cancer with type 2 diabetes

Study Timeline

• Study First Submitted: 2012-07-06
• Study First Submitted QC: 2012-07-10
• Study First Posted: 2012-07-11
• Status Verified: 2012-08
• Study Start: 2012-08
• Last Update Submitted: 2016-02-14
• Last Update Posted: 2016-02-17
• Primary Completion: 2016-10
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. 18-75 years old,gastric cancer ,can be performed operation
2. with type 2 diabetes,fasting blood glucose > 6.1mmol/L
3. without serious underlying diseases which may affect the metabolism and nutrient uptake
4. without serious underlying diseases which may affect anesthesia and operation
5. can be performed subtotal or total gastrectomy, predicted survival period > 6months
6. no other abdominal operation
7. preoperation consultation
8. informed consent

Exclusion Criteria

1. recurrent,metastasis or die
2. patient requests for quit
3. pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
total gastrectomy , Roux-en-Y	digestive tract reconstruction	-
Subtotal gastrectomy , BillrothⅠ	digestive tract reconstruction	-
total gastrectomy, jejunal interposition	digestive tract reconstruction	-
Subtotal gastrectomy , BillrothⅡ	digestive tract reconstruction	-

Trial Locations

Locations (1)

Tianjin Medical University Cancer Institute and Hospital; 🇨🇳 Tianjin, Tianjin, China