Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date Women
- Registration Number
- NCT03854383
- Lead Sponsor
- Abdelrahman Ali Fadel Youssef Mohamed
- Brief Summary
We will compare between using isosorbide mononitrate together with misoprostol versus the misoprostol alone in induction of labor in postdate women
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
- age (20-35 yrs)
- single fetus
- gestational age > 40weeks
- not in labor
- bishop score < 7
- no medical disorder
Exclusion Criteria
- Gestational age ≤40 weeks
- patient with a ripe cervix
- rupture of membranes
- suspected chorioamnionitis
- placenta previa
- history of major uterine surgery
- hypertonic uterine pattern
- contraindicated to receive PG
- fetal malpresentation
- multiple pregnancy
- intrauterine growth retardation
- women with any general medical disorder
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Misoprostol alone Misoprostol Enrolled women will receive 25 πg of misoprostol which will be placed intravaginally 4 hourly, maximum up to 5 doses Isosorbide mononitrate with misoprostol Isosorbide mononitrate Enrolled women will receive 25 πg of misoprostol together with 40 mg isosorbide mononitrate which will be placed intravaginally 4 hourly, maximum up to 5 doses Isosorbide mononitrate with misoprostol Misoprostol Enrolled women will receive 25 πg of misoprostol together with 40 mg isosorbide mononitrate which will be placed intravaginally 4 hourly, maximum up to 5 doses
- Primary Outcome Measures
Name Time Method The duration of induction to active phase interval 12 weeks Measure the time between the beginning of the induction to enter the active phase of labor
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ain Shams maternity hospital
🇪🇬Cairo, Egypt