Effect of Physical Activity Intervention on Overweight and Obese Patients With Endometrial Cancer

Not Applicable

Completed

• Conditions: Physical Activity; Weight Management; Endometrium Cancer
• Interventions: Behavioral: Physical activity

• Registration Number: NCT06312917
• Lead Sponsor: Peking University People's Hospital

Brief Summary

This study evaluated the clinical outcome of exercise management on patients with endometrial cancer treated with fertility preservation, including the effect of complete response rate, complete response time, recurrence rate, recurrence time, etc., and physical composition, to evaluate the effectiveness of physical activity on weight management.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-01
• Primary Completion: 2023-12-30
• Study Completion: 2024-02-01
• Study First Submitted: 2024-02-25
• Study First Submitted QC: 2024-03-08
• Study First Posted: 2024-03-15
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-20
• Last Update Posted: 2025-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 72

Inclusion Criteria

• Participants were patients who met the following predefined eligibility criteria: Ages 20-40; Overweight or obese; The pathological diagnosis was EC (endometrioid, grade I, no myometrium invasion or metastasis). Not pregnant; Be willing to comply with test requirements after being fully informed of all risks and inconveniences associated with the test.

Exclusion Criteria

• Recurrent or metastatic disease; Currently participating in regular exercise at least 2 days per week; Pregnant at the start of the study; Or unwilling to comply with research requirements. Patients also completed the Physical Activity Readiness Questionnaire (PAR-Q) through a telephone interview. Patients with one or more potential exercise-related safety risks were excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Physical activity group	Physical activity	Exercise intervention According to the guidelines of the American Sports Medicine Association (ACSM) and the National Fitness guidelines of the General Administration of Sport of China

Primary Outcome Measures

Name	Time	Method
Body weight	Enrollment，four months after the intervention	Body weight measured naked or wearing work clothes of known weight, an electronic weight scale is used to measure
BMI	Enrollment，four months after the intervention	Body mass index is a standard commonly used in the world to measure the degree of body fat and whether it is healthy.; The formula is BMI= weight ÷ height\*height
physical activity level	Enrollment，four months after the intervention	Physical activity energy was calculated using the formula of the International Physical Activity Questionnaire. Calculation Manual: Physical activity amount (MEt-minutes /week)= physical activity intensity MET value × physical activity time (minutes)/ day × activity days.

Secondary Outcome Measures

Name	Time	Method
triglyceride	Enrollment，four months after the intervention	Serum triglyceride determination is a routine item in lipid analysis. The measurement was made by drawing venous blood. Normal reference value of serum triglyceride: 0.45 \~ 1.69mmol/L
serum total cholesterol	Enrollment，four months after the intervention	Total cholesterol is the sum of all lipoproteins in the blood.The measurement was made by drawing venous blood. Suitable level for adults: 2.83\~5.20mmol/L(110\~200mg/dl)
Waist Hip Ratio	Enrollment，four months after the intervention	It is an indicator of the distribution of human body fat. It is the ratio of the waist and abdomen circumference marked by the umbilicus to the hip circumference marked by the anterior superior spine of the iliac (cm).

Trial Locations

Locations (1)

Peking University People's Hospital; 🇨🇳 Beijing, Beijing, China