How sugars impact on lean and overweight/obese humans
Completed
- Conditions
- Impaired glucose toleranceNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN11113396
- Lead Sponsor
- niversity of Fribourg - Faculty of Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 40
Inclusion Criteria
1. Healthy
2. Non-smokers
3. BMI between 18 and 39.9 kg/m2
4. 20-45 years old
Exclusion Criteria
1. Participants diagnosed as diabetics based on the following criteria: fasting glucose levels equal to or exceeds 126 mg/dL (7.0 mmol/L), and b) 2-h glucose equal to or exceeds 200 mg/dL (11.1 mmol/L)
2. Any medical condition which could interfere with the measured variables, e.g. cardiovascular-, gastrointestinal-, neurological-, and overt metabolic disorders
3. Subjects under current medication (either for acute or chronic illnesses)
4. Competition athletes, smokers, or overtly sedentary, or have eating disorders
5. Subjects who fear or have adverse reactions to cannulation
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Haemodynamics: Measurements will be performed continuously starting with a 30 min baseline and continued after the OGTT for another 120 min using a Task Force Monitor (CNSystems). Haemodynamic parameters are: Blood pressure (systolic and diastolic), heart rate, stroke volume<br>2. Blood parameters: Measurements will be performed at the end of the baseline (30 min) and after the OGTT consecutively every 30 min until the end of the OGTT, i.e. 120 min post-drink. Blood parameters are: Plasma glucose (glucose oxidase method) and plasma insulin (Elisa Kit)<br>
- Secondary Outcome Measures
Name Time Method