Evaluation of the Dermal Cooling System for Treatment of Common Skin Conditions
- Conditions
- Skin Lesion
- Interventions
- Device: Dermal Cooling System
- Registration Number
- NCT05270512
- Lead Sponsor
- R2 Dermatology
- Brief Summary
The purpose of this study is to evaluate whether the Dermal Cooling System can be used to elicit an improvement in the cosmetic appearance or physical symptoms of common skin conditions.
- Detailed Description
This is a prospective, non-randomized, open-label study to evaluate the effectiveness of the Dermal Cooling system to determine if cosmetic benefits or physical symptoms are achieved in common skin conditions.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 88
- Male or female subjects > 18 years of age.
- Subject has a skin condition amenable to cryosurgical treatment including, for example, psoriasis, atopic dermatitis, acne, rosacea, and melasma.
- Subject is willing to have skin exposed to cooling with the Dermal Cooling System.
- Subject is willing to have digital photographs taken of the treatment area and agrees to use of photographs for presentation, educational, or marketing purposes.
- Subject is willing to cover treated area or have very limited sun exposure and use an approved sunscreen of SPF 50 or higher on the treated area for the duration of the study, including the follow-up period, if requested.
- Subject has read and signed a written informed consent form.
- Subject is willing to comply with adjuvant topical regimen, as applicable.
- Subject agrees not to undergo any other procedure(s) in the treatment area during the study.
- Dermatological conditions (e.g. vitiligo, open wounds, infection, pre-cancerous or malignant lesions) in the location of the treatment sites that would, in the professional opinion of the investigator, potentially pose an increased risk to the subject
- Use of Accutane within the previous 6 months
- History of melanoma
- Subject is pregnant or intending to become pregnant during the study period
- Subject is lactating or has been lactating in the past 6 months
- Known history of illness or adverse reaction to cold insult (e.g., cryoglobulinemia, cold urticaria, paroxysmal cold hemoglobinuria, Reynaud's disease.
- History of abnormal wound healing or abnormal scarring
- Inability or unwillingness to comply with the study requirements.
- Current enrollment in a clinical study of any other unapproved investigational drug or device.
- Any other condition or laboratory value that would, in the professional opinion of the investigator, potentially affect response or participation in this clinical study, or would pose an unacceptable risk to the subject.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Treatment with Dermal Cooling System Dermal Cooling System Dermal Cooling System will be used in all eligible subjects.
- Primary Outcome Measures
Name Time Method Incidence of treatment-emergent adverse events Up to 12 months The safety of the treatment is determined by the incidence of device- or procedure-related serious adverse events.
Change in appearance in the treated area as determined by the Physician Global Assessment (PGA). up to 3 months Investigator assessment using Physician Global Assessment (PGA); graded from "4" (very much improved") to "0" (worse).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (4)
West Coast Research
🇺🇸Dublin, California, United States
Oak Dermatology
🇺🇸Naperville, Illinois, United States
Skin Search of Rochester, Inc.
🇺🇸Rochester, New York, United States
Dermatology, Laser and Vein Specialists of the Carolinas
🇺🇸Charlotte, North Carolina, United States