se of high definition transcranial direct current stimulation in negative symptoms of Schizophrenia and changes in proton magnetic resonance spectroscopic findings

Phase 3

Completed

• Conditions: Health Condition 1: F203- Undifferentiated schizophrenia

• Registration Number: CTRI/2019/05/018947
• Lead Sponsor: Central institute of psychiatry

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-04-30
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization,1992)

2.Age between 18- 60 years of either sex

3.The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) negative symptoms score of more than 15

4.Scale for Assessment of Negative Symptoms (SANS) score more than 20

5.Calgary Depression Scale for Schizophrenia (CDSS) score less than 7

6.Right handed

7.Patients giving written informed consent.

Exclusion Criteria

1.Presence of co-morbid neurological or other psychiatric disorder(s).

2.Patient with co morbid substance dependence, except nicotine and caffeine.

3.Having any metallic implants/parts in body

4.Subjects who have received Electroconvulsive therapy in past 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome of the study is change in negative symptoms score as assessed at the end of 2 weeks of HDtDCS treatment with the specially designed score sheet.Timepoint: PANSS, SANS, CGI, CDSS WILL BE APPLIED AT THE END OF 2 WEEKS & 6WEEKS

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes are changes in the levels of GABA, Glutamate, Glutamine, N-Acetyl Aspartate & N-Acetyl Aspartyl Glutamate in Dorsolateral Prefrontal Cortex using Proton MR Spectroscopic imaging and overall severity scores on CGI.Timepoint: Proton Magnetic Resonance Spectroscopy will be done before giving HD tDCS and after 2 sessions of HD tDCS and at the end of 2 weeks.