Effect of low dose Doxycycline as an adjuct to non-surgical periodontal therapy on the serum level of inflammatory mediators and lipid profile in advanced periodontitis
Phase 3
- Conditions
- advanced periodontitis disease.Chronic Periodontitis
- Registration Number
- IRCT138904071081N4
- Lead Sponsor
- Vice-Chancellor for Research, Guilan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age 40 to 70 years , Being systemically healthy with no history of Arthritis, GI disorders, skin diseases, bronchitis, Diabetes Mellitus, pregnancy or breast feeding, Body mass index between 20-27, Existence of at least 20 standing teeth without untreated periapical lesions, and at least 15% of sites with more than or equal to 5 mm of clinical attachment loss and evidence of bone loss in at least two quadrants.
Exclusion criteria: Being under treatment with drugs such as: anticoagulants, steroids, anti-inflammatory drugs, immunosuppressant drugs within past 6 months, any periodontal treatment within past three months, heavy smokers
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum inflammatory mediator: TNF-a. Timepoint: Baseline and one month after the intervention. Method of measurement: Laboratory test: ELIZA.;Serum inflammatory mediator: IL-6. Timepoint: Baseline and one month after the intervention. Method of measurement: Laboratory test: ELIZA.;Serum cholesterol levels. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.;Serum level of LDL. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.;Serum level of HLDL. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.;Serum triglyceride levels. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.
- Secondary Outcome Measures
Name Time Method Periodontal parameter: Probing Pocket Depth. Timepoint: Baseline and one month after the intervention. Method of measurement: Calibrated periodontal probe.;Periodontal parameter: Clinical Attachment Level. Timepoint: Baseline and one month after the intervention. Method of measurement: Calibrated periodontal probe.;Periodontal parameter: Bleeding on probing. Timepoint: Baseline and one month after the intervention. Method of measurement: Bleeding points index ( Lenox & Kopczyk).;Dental Plaque. Timepoint: Baseline and one month after the intervention. Method of measurement: Oleary plaque index.