Retinal scanning for biomarker discovery in multiple sclerosis

Completed

Conditions: Multiple sclerosis
Nervous System Diseases

Registration Number: ISRCTN77452114

Lead Sponsor: niversity of Edinburgh (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 100

Inclusion Criteria

1. Competent and consenting adults between the ages of 18 and 75 years
2. Patients with MS including those with clinically isolated syndrome, relapse-remitting, secondary progressive and primary progressive - 25 in each group
3. Participants must be able to manoeuvre themselves to the retinal imaging room in the Rowling Clinic unaided, sit upright in a chair or wheelchair, comfortably position themselves for imaging, and be able to listen to and act upon directions for fixing their gaze

Exclusion Criteria

1. People who cannot manoeuvre themselves to the retinal imaging room in the Rowling Clinic unaided, who cannot sit upright in a chair or wheelchair, who cannot comfortably position themselves for imaging, or who would struggle with listening to or acting upon directions for fixing their gaze
2. People under the age 18 or over the age of 75

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The change in retinal structure and function as measured by computation analysis of imaging.

Secondary Outcome Measures

Name	Time	Method
Visual acuity (full contrast and reduced contrast), refractive error (from glasses or focimeter or refraction), and expanded disability status scale (EDSS). <br><br>Correlation will be made with information on diagnosis, subtype, date of onset of symptoms, date of diagnosis, history of optic neuritis, history of other eye diseases, and any current visual symptoms. This will include phenotypic description, disease metric correlation, and integration of retinal image measurements into a combined score.