Effect of intratracheal Dexmedetomidine to attenuate cardiovascular and airway responses to tracheal extubation.

Introduction: Peri-Extubation cough is an unpleasant event, prevention of which has been studied with multiple

pharmacological strategies among which intravenous Dexmedetomidine has emerged as one of the preferred drug.

Intratracheal route is attractive as it is easy to use and moreover it avoids hypotension and bradycardia associated

with intravenous drug administration. But, there is lack of data exploring the efficacy, dosage and adverse effects

of intratracheal Dexmedetomidine.

Aims and Objectives :

1.To assess the effectiveness of intratracheal Dexmedetomidine in different doses to attenuate the cardiovascular

and airway responses to tracheal extubation.

2.To observe the adverse effects of Dexmedetomidine.

Materials and Methods:

This study will be conducted on 90 Patients with ASA I and II status scheduled for surgery under general

anaesthesia. They will be randomly divided into three groups – Group D1, Group D2, and Group N. 30 minutes

prior to extubation these groups will receive intratracheal dexmedetomidine 0.3mic/kg, 0.5mic/kg and 2ml NS

respectively. Hemodynamics responses, time taken for extubation, quality of extubation and time to achieve the

Ramsay sedation score of 3 will be recorded.