The Effect of the Combination of Whole Body Vibration and External Load Exercise Training on Cardiovascular and Autonomic Function in Obese Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Arterial Stiffness
研究概览
简要总结
Obesity is directly related to arterial dysfunction and negatively associated to muscle strength. High-intensity resistance exercise is the favored modality to offset muscle weakness, yet, adverse effects on arterial function (pulse wave velocity, wave reflection, and aortic and brachial blood pressures) have been observed. Conventional unloaded-whole body vibration training (WBVT) has improved arterial function in overweight/obese women but appears to be low-intensity. Nevertheless, the effects of moderate-intensity (by adding external load) WBVT on arterial and muscle function are unknown. Therefore, the purpose of this study was to examine whether loaded-WBVT would induce greater benefits than unloaded-WBVT on arterial and muscle function in young overweight/obese women. Furthermore, we examined whether these changes were similar to healthy lean young women.
详细描述
The purpose of this study was to determine the effects of 6 weeks of loaded-WBVT on arterial stiffness, peripheral and aortic blood pressures, wave reflection, endothelial function, and muscle strength in overweight/obese women.
The specific aims of the study were:
- To examine whether 6 weeks of loaded-WBVT was more beneficial than unloaded-WBVT in decreasing cardiovascular risk factors by assessing arterial stiffness (aortic, leg, and systemic), aortic blood pressures and wave reflection, brachial blood pressures, autonomic function, endothelial function, and blood flow (leg and arm).
- To determine the extent to which 6 weeks of loaded-WBVT improved body composition measured by changes in fat and lean mass utilizing dual-energy x-ray absorptiometry and waist circumference.
- To evaluate the effect of 6 wees of loaded-WBVT on muscle strength by using the one-repetition maximum test (leg press and chest press exercises).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •18 to 25 years of age
- •Sedentary (less than 120 min per wk)
- •15 lean (Body mass index of 18-25 kg/m²)
- •45 overweight/obese (Body mass index of 27-39.9 kg/m²)
排除标准
- •Younger than 18 or older than 25 years of age
- •Body mass index lower than 18 or higher than 39.9
- •Physically active or competitively active
- •Irregular menstrual cycle
- •Use of dietary supplementations (e.g.,L-arginine,L-citrulline,antioxidants)
- •Any contraindications to exercise and/or whole-body vibration exercise
结局指标
主要结局
Arterial Stiffness
时间窗: 6 weeks
Aortic, leg, and systemic pulse wave velocity acquired through non-invasive sensors.
Pressure Wave Reflection
时间窗: 6 weeks
Augmentation index acquired through radial tonometry.
次要结局
- Autonomic Function(6 weeks)
- Blood Pressures(6 weeks)
- Endothelial Function(6 weeks)
- Body Composition(6 weeks)
- Muscle Strength(6 weeks)
研究者
Arturo Figueroa
Associate Professor
Florida State University