Study of CPAP as Intervention After Lung Resection

Not Applicable

Completed

• Conditions: Lung Cancer; Pulmonary Complications
• Interventions: Procedure: Cpap

• Registration Number: NCT01285648
• Lead Sponsor: University of Campinas, Brazil

Brief Summary

The aim of this study was to compare the oxygenation index (OI), dyspnea, and pain scale and evaluate the duration of thoracic drainage and pleural air leaks after lung resection in two groups of patients: chest physiotherapy (CP) patients and combined CP and Continuous Positive Airway Pressure (CPAP) patients.

Detailed Description

In pulmonary resection surgery complications that lead to significant functional losses of the lung parenchyma and alterations in the ventilatory function may trigger retention of secretions, atelectasis, pneumonia and respiratory failure, which prolong the duration of mechanical ventilation and hospitalisation and contribute to the increase in risk of mortality.

In this study the oxygenation index (OI), Borg Scale, pain scale and the presence and duration of thoracic drainage was determined in the immediate postoperative (POi) period and in the first and second postoperative (PO1, PO2) days in 40 patients who underwent elective lung resection.

Similar to Chest Physiotherapy, the preventive application of CPAP in the postoperative period after lung resection in our study also appeared to be a safe technique, which allowed improved oxygenation without increasing air leaks through the thoracic drains.

Study Timeline

• Study Start: 2007-11
• Primary Completion: 2009-12
• Study Completion: 2010-02
• Status Verified: 2011-01
• Study First Submitted: 2011-01-25
• Study First Submitted QC: 2011-01-26
• Last Update Submitted: 2011-01-26
• Study First Posted: 2011-01-28
• Last Update Posted: 2011-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• medical diagnosis of lung cancer and an indication for lung resection (lobectomy, bilobectomy and pneumonectomy) with posterolateral thoracotomy;
• aged between 40 and 75 years.

Exclusion Criteria

• Patients who refused to participate in the survey;
• lung resection with incisions other than posterolateral;
• patients who had contraindications to the use of noninvasive ventilation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Cpap	Cpap	This group joined chest physiotherapy with CPAP via nasal masks for two hours.CPAP was continued from the immediate postoperative day until the second postoperative day, twice a day.
Chest Physiotherapy	Cpap	Chest Physiotherapy consisted of bronchial hygiene techniques and pulmonary expansion, in addition to exercises, and received oxygen supplementation to maintain the pulse oxymetry saturations \> 90%.

Primary Outcome Measures

Name	Time	Method
Bubbling drains	From immediate postoperative until fifth, along the study, in a total of one year	From the immediate postoperative day until hospital discharge, the presence of chest tubes and the occurrence of air leaks in them as evidenced by the bubbling of the water seal were recorded. The maintenance and removal of drains or their use with wall suction were determined by applying the medical protocol of the institution through the analysis of X-rays and the amount of drained fluid.

Secondary Outcome Measures

Name	Time	Method
Pain score	Reported pain score after lung resection, along the study, during one year	Before beginning the chest physiotherapy protocols, the patient was asked to rate their pain from zero to ten according to its intensity (the larger the score, the greater the intensity of pain).

Trial Locations

Locations (1)

Campinas State University; 🇧🇷 Campinas, São Paulo, Brazil