Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index

Completed

• Conditions: Acute Respiratory Failure

• Registration Number: NCT00632320
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.

Detailed Description

98 ready for weaning patients were included and divided into success (n=71) and failure (n=27) groups based upon their weaning outcome. Before weaning, the RSBI values were determined under the patients disconnecting from the ventilator (RA-no ventilator) and still connecting to the ventilator with 4 different settings (fraction of inspired oxygen (FiO2) 21 or 40% combined with continuous positive airway pressure (CPAP) 0 or 5 cm H2O). The patients were extubated after completing the weaning trials. Successful weaning was defined as patients free from the ventilator for over 48 hours.

Study Timeline

• Study Start: 2004-10
• Primary Completion: 2004-12
• Study Completion: 2005-08
• Status Verified: 2008-03
• Study First Submitted: 2008-03-02
• Study First Submitted QC: 2008-03-07
• Last Update Submitted: 2008-03-07
• Study First Posted: 2008-03-10
• Last Update Posted: 2008-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• intubated medical patients with mechanically ventilated more than 48 hours
• clinically ready for weaning
• Glasgow coma scales were at least 8
• their ventilator settings were: assist-controlled, pressure support (PS)or synchronized intermittent mandatory ventilation plus PS mode, FiO2 40% or less, positive end-expiratory pressure 5 cm H2O or less, and sensitivity setting on 1 L/min. Their arterial blood gases results were acceptable

Exclusion Criteria

• having ongoing lung or neuromuscular disease and signs of increased intracranial pressure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The patients connecting or disconnecting to the ventilators affected the RSBI values but not their predictive accuracies.	Before the patient processing weaning trials

Secondary Outcome Measures

Name	Time	Method
Changes in FiO2 and CPAP settings have no effect on RSBI values but ventilator methods with FiO2 21% have higher incidence of adverse reactions.	Before the patient processing weaning trials

Trial Locations

Locations (1)

Respiratory Therapy Intensive Care Unit, Taipei Veterans General Hospital; 🇨🇳 Taipei, Taiwan